Advanced Solid TumorMetastatic Solid Tumor
The purpose of this study is to describe the safety, tolerability and early signs of efficacy of the antibody-cytokine f…
Hamburg, GermanyEst. completion Dec 2026
Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Locally Recurrent Head and Neck Squamous Cell CarcinomaLocally Recurrent Hypopharyngeal Squamous Cell CarcinomaLocally Recurrent Laryngeal Squamous Cell CarcinomaLocally Recurrent Oral Cavity Squamous Cell CarcinomaLocally Recurrent Oropharyngeal Squamous Cell CarcinomaStage II Laryngeal Cancer AJCC v8Stage II Lip and Oral Cavity Cancer AJCC v8Stage II Oropharyngeal (p16-Negative) Carcinoma AJCC v8Stage III Laryngeal Cancer AJCC v8Stage III Lip and Oral Cavity Cancer AJCC v8Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8Stage IVA Laryngeal Cancer AJCC v8Stage IVA Lip and Oral Cavity Cancer AJCC v8Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8Stage IVB Laryngeal Cancer AJCC v8Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
This phase II trial tests the addition of chemotherapy, with carboplatin and paclitaxel, or chemo-immunotherapy, with ca…
Tucson, United StatesEst. completion Feb 1, 2033
Acute Myeloid LeukemiaAcute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative NeoplasmAcute Myeloid Leukemia Post Cytotoxic TherapyAcute Myeloid Leukemia, Myelodysplasia-RelatedMyelodysplastic Syndrome
This MyeloMATCH Master Screening and Reassessment Protocol (MSRP) evaluates the use of a screening tool and specific lab…
Birmingham, United StatesEst. completion May 15, 2029
PROSTATE CANCERMetastatic Prostate CancerMetastatic Prostate Carcinoma
The purpose of this study is to determine whether a 16-week supervised, clinic-based circuit training intervention utili…
Boston, United StatesEst. completion Aug 28, 2027
Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8Anatomic Stage IIIC Breast Cancer AJCC v8Estrogen Receptor-Positive Breast CarcinomaHER2-Negative Breast Carcinoma
This phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone thera…
Jonesboro, United StatesEst. completion Jul 31, 2029
Lung Cancer
The overall objective of this mixed methods study is to: 1) Refine the Emergency Department Lung Cancer Screening (ED-LC…
Indianapolis, United StatesEst. completion Jun 1, 2027
Proteus SyndromePIK3CA Related Overgrowth Spectrum
This study will examine rare congenital disorders that involve malformations and abnormal growth. It will focus on patie…
Bethesda, United States
Metastatic Breast Cancer
This is an umbrella study evaluating the efficacy and safety of multiple treatment combinations in participants with met…
Duarte, United StatesEst. completion Sep 30, 2030
Ovarian Cancer
This is a single site, open label, Phase 1 study using a 3 + 3 dose escalation design in two cohorts of adults with recu…
Palo Alto, United StatesEst. completion Jan 2027
Acute Lymphoblastic Leukemia, Pediatric
The study aims to conduct a real-world investigation of children with Philadelphia chromosome-positive acute lymphoblast…
Hangzhou, ChinaEst. completion Sep 2026
ARDS (Moderate or Severe)
To verify whether the transpulmonary pressure-guided mechanical ventilation strategy can reduce right ventricular involv…
Beijing, ChinaEst. completion Mar 31, 2028
Epidermal Growth FactorEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor Gene MutationNon Small CellNon Small Cell LungNon Small Cell Lung CancerHead and NeckHead and Neck CancerHead and Neck CancersHead and Neck Squamous Cell CancerHead and Neck Squamous Cell CarcinomaHead and Neck Squamous Cell Carcinoma HNSCCNSCLC (Non-small Cell Lung Cancer)HNSCCEGFR
A phase 1 study to determine the safety, tolerability, PK, PD, and preliminary anti-tumor activity of ascending doses of…
Los Angeles, United StatesEst. completion Jul 2029
Esophageal CancerGastric (Stomach) CancerGastric AdenocarcinomaGastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal CarcinomaEsophageal CarcinomaGastric (Cardia, Body) Cancer
Purpose of the Study:
This clinical study investigates whether a shorter or longer duration of systemic therapy before …
Amsterdam, NetherlandsEst. completion Nov 2031
Endometrial CarcinomaEndometrial Clear Cell AdenocarcinomaEndometrial Dedifferentiated CarcinomaEndometrial Endometrioid AdenocarcinomaEndometrial Mixed Cell AdenocarcinomaEndometrial Serous AdenocarcinomaEndometrial Undifferentiated CarcinomaUterine Corpus Malignant Mixed Mesodermal (Mullerian) Tumor
This phase III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta \[TM\]) or pertuzumab, t…
Birmingham, United StatesEst. completion Oct 31, 2027
Hepatocellular CarcinomaLiver Cancer, AdultLiver NeoplasmMetastatic Liver Cancer
This is an open-label, multi-center, Phase 1/2 clinical trial evaluating the safety, tolerability, and efficacy of ECT20…
Duarte, United StatesEst. completion Dec 31, 2027
Neuroendocrine Tumors
Neuroendocrine tumours (NETs) are slow growing cancers, which commonly present as metastatic incurable disease. Some neu…
Sydney, AustraliaEst. completion Sep 2027
Pancreatic Cancer
This trial is a single-arm, prospective, multi-center clinical trial designed to demonstrate that stereotactic adaptive …
Birmingham, United StatesEst. completion Mar 2028
Advanced Cancers
This is a Phase I clinical study aimed at evaluating the safety and pharmacokinetics of TQB2922 subcutaneous injection i…
Beijing, ChinaEst. completion Dec 2029
Intrahepatic Cholangiocarcinoma
Underlying disease mechanisms are fundamental for correct treatment selection and patient management in highly invasive …
Bergamo, ItalyEst. completion May 2027
Castrate Resistant Prostate CancerMetastatic Castration-resistant Prostate CancerProstate CancerProstate Carcinoma
This is a single-center, open-label, study of Prostate-Specific Membrane Antigen (PSMA)-targeted radionuclide therapy wi…
San Francisco, United StatesEst. completion May 31, 2027