Lung NeoplasmsNeoadjuvant TherapyImmunotherapyMinimal Residual Disease
This study is a prospective single-arm clinical trial targeting patients with stage IB-IIIA non-small cell lung cancer (…
Beijing, ChinaEst. completion Oct 31, 2027
Esophageal Squamous Cell CarcinomaImmunotherapyBiomarkers
To evaluate the efficacy and safety of adebrelimab with or without induction chemotherapy followed by concurrent chemora…
Fuzhou, ChinaEst. completion Dec 2027
B-AllAcute Lymphoblastic Leukemia
Background:
B-cell acute lymphoblastic leukemia (B-ALL) is a type of blood cancer. Some people with B-ALL have a gene m…
Bethesda, United StatesEst. completion Jun 30, 2030
Acute Lymphoblastic LeukemiaB-All
Background:
Acute lymphoblastic leukemia (ALL) is a type of blood cancer. Chimeric antigen receptor (CAR) therapy invol…
Bethesda, United StatesEst. completion Jan 31, 2030
Lung Cancer
This study aims to evaluate whether femtosecond laser imaging combined with FastLung AI model can provide intraoperative…
Shanghai, ChinaEst. completion Oct 30, 2026
Relapsed/Refractory Multiple Myeloma
The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in vario…
Birmingham, United StatesEst. completion Nov 2026
Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedHigh Grade B-Cell LymphomaTransformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
This phase I trial studies the side effects and best dose of mosunetuzumab when given together with polatuzumab vedotin …
Duarte, United StatesEst. completion Jun 30, 2027
Ganglioneuroblastoma, NodularNeuroblastoma
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care su…
Birmingham, United StatesEst. completion Dec 31, 2029
Lymphoplasmacytic LymphomaWaldenstrom Macroglobulinemia
This phase II trial studies the effects of venetoclax and rituximab in comparison to ibrutinib and rituximab or zanubrut…
Tucson, United StatesEst. completion Mar 31, 2028
Non-small Cell Lung Cancer
This is a study evaluating the efficacy and safety of calderasib with pembrolizumab as first-line treatment in participa…
Bakersfield, United StatesEst. completion Jan 24, 2028
Ovary CancerCervical CancerEndometrial Cancer
Para-aortic lymphadenectomy plays an important role in the surgical treatment of major gynecological malignancies (ovari…
Guangzhou, ChinaEst. completion May 31, 2028
Polycythemia Vera
The trial will be a phase III, randomised-controlled, multi-centre, international, open-label trial consisting of ruxoli…
Aberdeen, United KingdomEst. completion Oct 31, 2028
Malignant Pleural Mesothelioma, Advanced
This Phase 1b/2, open-label, multicenter, single-arm study evaluates the safety and efficacy of ivonescimab in combinati…
Shanghai, ChinaEst. completion Nov 30, 2028
MastocytosisMonoclonalBone MarrowTryptase
This study will examine growth factors that promote and inhibit mast cell proliferation resulting in mastocytosis, a dis…
Bethesda, United States
Malignancy, HematologicNeoplasms, HematologicNeoplasms, HematopoieticBlood CancerHematological NeoplasmsHematopoietic MalignanciesDysmyelopoietic SyndromesHematopoetic MyelodysplasiaMyeloid Leukemia, AcuteNonlymphoblastic Leukemia, AcuteLeukemia, Lymphocytic, Acute
Background:
Blood cancers (such as leukemias) can be hard to treat, especially if they have mutations in the TP53 or RA…
Bethesda, United StatesEst. completion Apr 30, 2029
HLA-A*0201 Positive Cells PresentClear Cell Sarcoma (CCS)
This is a multi-center, open label, phase II study of tebentafusp in patients with unresectable or metastatic clear cell…
Los Angeles, United StatesEst. completion Oct 1, 2030
Advanced Solid Tumor
This study will evaluate the safety and efficacy of DS-1103a combination therapy in participants with advanced solid tum…
Sarasota, United StatesEst. completion May 31, 2029
B-Cell Acute Lymphoblastic Leukaemia
The IntReALL BCP 2020 study aims to review recent developments and findings regarding chemoimmunotherapy with inotuzumab…
Vienna, AustriaEst. completion Mar 31, 2033
Waldenstrom MacroglobulinemiaLymphoplasmacytic LymphomaMonoclonal B-Cell LymphocytosisSmall Lymphocytic LymphomaCLL (Chronic Lymphocytic Leukemia)
Background
The development of new technologies now allow scientists to investigate the molecular basis and clinical man…
Bethesda, United States
Inherited Bone Marrow Failure SyndromeFamilial Platelet Disorder With Predisposition to Myeloid Malignancies
Background:
Runt-related transcription factor 1 (RUNX1) gene regulates the formation of blood cells. People with mutati…
Bethesda, United StatesEst. completion Oct 30, 2026