Very Rare TumorsVery Rare CancersOther Solid TumorsSolid TumorPediatric Rare Tumors
Background:
All childhood cancers are rare, but some are called very rare. Very rare cancers are diagnosed in 2 or fewe…
Bethesda, United StatesEst. completion Apr 1, 2035
Muscle Invasive Bladder Urothelial CarcinomaMuscle Invasive Renal Pelvis Urothelial CarcinomaMuscle Invasive Ureter Urothelial CarcinomaMuscle Invasive Urethral Urothelial CarcinomaStage II Bladder Urothelial Carcinoma AJCC v6 and v7Stage III Bladder Urothelial Carcinoma AJCC v6 and v7Stage IV Bladder Urothelial Carcinoma AJCC v7
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, kidney, ureter or uret…
Phoenix, United StatesEst. completion Sep 2, 2030
B-cell Acute Lymphoblastic LeukemiaDiffuse Large B-cell LymphomaBurkitt LymphomaNeuroblastomaEwing Sarcoma
Substudy 01A is part of a platform study. The purpose of this study is to assess the efficacy and safety of zilovertamab…
Los Angeles, United StatesEst. completion Mar 31, 2029
Recurrent GlioblastomaGlioblastoma IDH (Isocitrate Dehydrogenase) WildtypeRelapsed CancerRecurrent TumorGlioblastoma MultiformeRecurring GlioblastomaBrain and Central Nervous System TumorsGliomaGlioblastomasGrade IV AstrocytomaGBMRecurrent Glioma (Glioblastoma Multiforme)High Grade GliomaGlioma, MalignantBrain Cancer
Background:
Glioblastoma is a common brain cancer in adults. Treatment includes surgery, radiation, and chemotherapy. B…
Bethesda, United StatesEst. completion Dec 31, 2030
LeukemiaLymphomaMultiple MyelomaMyelodysplastic Syndromes (MDS)Myeloproliferative Neoplasm
Cancer and treatment-related cognitive changes, such as thinking or remembering, hinder resumption of normal routine and…
Omaha, United StatesEst. completion Jul 2027
Locally Advanced Cervical AdenocarcinomaLocally Advanced Cervical Adenosquamous CarcinomaLocally Advanced Cervical Squamous Cell CarcinomaStage IIIA Cervical Cancer FIGO 2018Stage IIIB Cervical Cancer FIGO 2018Stage IIIC1 Cervical Cancer FIGO 2018Stage IIIC2 Cervical Cancer FIGO 2018Stage IVA Cervical Cancer FIGO 2018
This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to…
Birmingham, United StatesEst. completion Dec 31, 2030
Breast Atypical Ductal HyperplasiaBreast Atypical Lobular HyperplasiaBreast CarcinomaBreast Ductal Carcinoma In SituBreast Lobular Carcinoma In SituEstrogen Receptor-Positive Breast Carcinoma
This phase II trial evaluates response-guided low-dose tamoxifen for reducing breast density in women who are at higher …
Tucson, United StatesEst. completion Mar 31, 2028
B-AllAcute Lymphoblastic Leukemia
Background:
Chimeric antigen receptor T-cell (CART) therapy is a form of immunotherapy which can be used to treat peopl…
Los Angeles, United StatesEst. completion Dec 31, 2026
Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Locally Recurrent Head and Neck Squamous Cell CarcinomaLocally Recurrent Hypopharyngeal Squamous Cell CarcinomaLocally Recurrent Laryngeal Squamous Cell CarcinomaLocally Recurrent Oral Cavity Squamous Cell CarcinomaLocally Recurrent Oropharyngeal Squamous Cell CarcinomaMetastatic Head and Neck Squamous Cell CarcinomaMetastatic Hypopharyngeal Squamous Cell CarcinomaMetastatic Laryngeal Squamous Cell CarcinomaMetastatic Melanoma
Myasthenia Gravis
The purpose of this study is to evaluate the efficacy and safety of nipocalimab compared to placebo in participants with…
Paradise Valley, United StatesEst. completion Nov 17, 2023
Lymphoma, Non-HodgkinLymphoma, FollicularLymphoma, Large B-Cell, Diffuse
Researchers are looking for new ways to treat 2 types of non-Hodgkin lymphoma (NHL) called follicular lymphoma (FL) and …
Denver, United StatesEst. completion Jul 1, 2030
Cutaneous T Cell LymphomaPeripheral T Cell Lymphoma
This research is being done to study the safety of implanting and retrieving a microdevice that releases up to 19 drugs …
Boston, United StatesEst. completion Jul 31, 2027
AIDS-related LymphomaHIV Infection
The goal of this clinical trial is to evaluate the efficacy and safety of different antiretroviral therapy (ART) strateg…
Shanghai, ChinaEst. completion Jul 2028
Proteus SyndromePIK3CA Related Overgrowth Spectrum
This study will examine rare congenital disorders that involve malformations and abnormal growth. It will focus on patie…
Bethesda, United States
Advanced Solid TumorsMalignant Neoplasm
Researchers are looking for new ways to treat people with certain advanced solid tumors. Advanced means the cancer has s…
Birmingham, United StatesEst. completion Oct 25, 2028
Hormone Receptor Positive HER-2 Negative Breast CancerMetastatic Breast CancerRecurrent Breast Cancer
PUMA-ALI-1201 is a randomized, dose optimization, multicenter, Phase 2 study of alisertib administered in combination wi…
Birmingham, United StatesEst. completion Dec 30, 2027
Diffuse Large B-cell Lymphoma (DLBCL)CardiotoxicityLymphoma
This trial is to evaluate if dexrazoxane is safer and more effective than liposomal doxorubicin in preventing heart fail…
Boston, United StatesEst. completion Dec 31, 2030
Cancer
The purpose of this study is to examine a psychotherapeutic and psycho-educational intervention offered in virtual setti…
San Francisco, United StatesEst. completion Dec 31, 2026
Multiple MyelomaLymphoma
Higher gut microbiome diversity has been associated with improved survival following autologous stem cell transplantatio…
Omaha, United StatesEst. completion Jul 2028
Cancer Harboring BRAF AlterationsHGGLGGSolid Tumors
The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with BRAF a…
Beverly Hills, United StatesEst. completion Dec 31, 2027