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Showing 320 trials for Crohn's Disease
A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative ColitisRecruiting
Ulcerative ColitisCrohn Disease
Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiot…
Roma, ItalyEst. completion Sep 14, 2026
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Autologous Stem Cell Transplant for Crohn's DiseasePhase 2Recruiting
Crohn Disease
Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant complications and discomfort in the st…
New York, United StatesEst. completion Oct 2028
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Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel DiseaseRecruiting
Inflammatory Bowel DiseasesUlcerative ColitisCrohn Disease
This research is studying whether changing an individual's behaviors may have an impact as a treatment or outcome for in…
Ann Arbor, United StatesEst. completion Mar 2028
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A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's DiseasePhase 3Recruiting
Moderately to Severely Active Crohns Disease
This Phase III, multicenter, double-blind, placebo-controlled treat-through study will evaluate the efficacy and safety …
Dothan, United StatesEst. completion Dec 31, 2028
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A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community SettingPhase 4Recruiting
Ulcerative ColitisCrohn's Disease
Ulcerative Colitis (UC) and Crohn's Disease (CD) are long-term conditions in the gut that can cause diarrhea, swelling (…
Birmingham, United StatesEst. completion Oct 1, 2027
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Cranberry and Gut Health in Crohn's DiseaseEARLY_PHASE1Recruiting
Crohn Disease (CD)Crohn Disease
This study is investigating whether a cranberry-based dietary supplement, rich in polyphenols and fiber, can enhance gut…
Worcester, United StatesEst. completion Aug 15, 2026
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A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's DiseasePhase 2Recruiting
Inflammatory Bowel DiseasesCrohn's Disease
This is a Phase 2, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety o…
Lancaster, United StatesEst. completion Sep 2028
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A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's DiseasePhase 2Recruiting
Colitis, UlcerativeCrohn Disease
Study IIBD is a master protocol that will support a collection of individual sub studies that share key design component…
Scottsdale, United StatesEst. completion Jun 2027
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Evaluation of the Accuracy of Immunostaining of Claudin 2 to Detect Active or Inactive Inflammation in Endoscopic Biopsies of IBDRecruiting
Ulcerative Colitis (UC)Crohn Disease
In view of the increasing evidence of the importance of mucosal healing as a combination of endoscopic and histologic he…
San Donato Milanese, ItalyEst. completion Feb 2027
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Immune Regulation in Ulcerative Colitis or Crohn s DiseaseRecruiting
Inflammatory Bowel DiseaseUlcerative ColitisChrohn's Disease
This study will investigate in patients with Crohn s disease and ulcerative colitis how the body s immune system control…
Bethesda, United States
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A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's DiseasePhase 2Recruiting
Crohn Disease
The main purpose of this study is to see how the safety and efficacy of a farnesoid X receptor (FXR) agonist (LY4395089)…
Scottsdale, United StatesEst. completion Jun 2027
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Assessment and Educational Intervention to Reduce Ultra-processed Food Consumption in Pediatric Patients With IBDRecruiting
IBDCrohn Disease (CD)Ulcerative Colitis (UC)Inflammatory Bowel Disease (IBD)Ultra Processed FoodNutrition AssessmentDGBI
This study explores whether simple nutrition education can help children and teens with inflammatory bowel disease (IBD)…
Hartford, United StatesEst. completion Dec 1, 2026
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Open-label Single-arm Study to Assess the Efficacy of Mirikizumab in Patients With Inflammatory Strictures Due to CDPhase 4Recruiting
Crohn Disease
This is an open-label, single-arm, phase 4 study to assess the safety and efficacy of mirikizumab in approximately 60 pa…
Orlando, United StatesEst. completion Sep 1, 2027
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Comparing Over the Counter Pain Medicines for Discomfort in Crohn's Disease (AVID-CD)Recruiting
Crohn's Disease (CD)Dysmenorrhea Primary
The purpose of this pilot study is to prepare for a larger study that will compare the effectiveness and safety of two c…
Chapel Hill, United StatesEst. completion Jul 2028
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A Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's DiseasePhase 3Recruiting
Moderately to Severely Active Crohns Disease
This phase III, double-blind, multi-center treat-through study will evaluate the efficacy and safety of Afimkibart (also…
Parkville, AustraliaEst. completion May 31, 2030
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A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)Phase 3Recruiting
Crohn's Disease
The purpose of this protocol is to evaluate the efficacy and safety of tulisokibart in participants with moderately to s…
Dothan, United StatesEst. completion Oct 30, 2028
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Comparison of the Efficacy of Different Biologic Agents in Preventing Postoperative Endoscopic Recurrence of Crohn's DiseaseRecruiting
Inflamatory Bowel DiseaseCrohn Disease (CD)
This retrospective cohort study aims to compare the efficacy of different biologics in preventing postoperative endoscop…
Shanghai, ChinaEst. completion Sep 30, 2026
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Fecal Microbiota Transplantation in Pediatric Crohn's DiseaseRecruiting
Crohn Disease
This study will test the safety and effectiveness of fecal microbiota transplantation (FMT) plus partial enteral nutriti…
Wuhan, ChinaEst. completion May 31, 2027
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Fecal Microbiota Transplantation as the First-line Treatment in Active Pediatric Crohn's DiseaseRecruiting
Crohn Disease
To explore the safety and effectiveness of repeated and multiple fecal microbiota transplantations (FMTs) plus partial e…
Wuhan, ChinaEst. completion Jun 30, 2027
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Surgery vs Biologics for Treating Stricturing CD--a RCTRecruiting
Crohn Disease
The management of stricturing Crohn's disease (CD) remains challenging. Although surgical resection may be the final way…
Nanjing, ChinaEst. completion Jul 1, 2026
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