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Data source: ClinicalTrials.gov
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Showing 1478 trials for Obesity & Metabolic Health
Translational Health Research Into Vascular and Neurocognitive Effects of Weight LossPhase 4Recruiting
Class I/II Obesity
The goal of this clinical trial is to learn about the nature of brain abnormalities associated with excess body fat in h…
Montreal, CanadaEst. completion Dec 1, 2028
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A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or ObesityPhase 1Recruiting
Overweight and Obesity
The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ascending dose…
Phoenix, United StatesEst. completion Dec 2027
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Redefining Evaluation of Adiposity and Leanness: Broadening Objective Diagnostics for ObesityRecruiting
Obesity & Overweight
The purpose of this study is to evaluate body composition across a variety of medical, professional, and commercial devi…
Phoenix, United StatesEst. completion Nov 30, 2026
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Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular SystemRecruiting
Metabolic DiseaseObesityLi-Fraumeni SyndromeCardiomyopathyAtherosclerosisInflammatory Disease
Background: \- Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory o…
Washington D.C., United States
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Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight LossPhase 2Recruiting
Overweight , ObesityAdults
A study of ALV-100 to assess efficacy, safety and tolerability among participants with overweight or obesity who have pr…
Birmingham, United StatesEst. completion Aug 24, 2027
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Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without DiabetesPhase 2Recruiting
Overweight or Obesity
This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this d…
Mobile, United StatesEst. completion Jan 21, 2028
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Early Tracking of Childhood Health Determinants (ETCHED) StudyRecruiting
Diabetes MellitusObesityFatty Liver
Background: Children s weight has increased sharply in recent years. This may put them at higher risk for health proble…
Phoenix, United StatesEst. completion Dec 31, 2041
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Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood EnvironmentsRecruiting
Obesity
Background Obesity and physical inactivity contribute substantially to cardiovascular disease risk, diabetes, hypertens…
Bethesda, United StatesEst. completion Aug 4, 2027
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Changes in Intestinal Permeability and Systemic Inflammation Following Fast Food Overfeeding.Recruiting
Obesity & Overweight
The purpose of this study is to investigate whether lifestyle factors can alter gut barrier integrity and whether disrup…
Hellerup, DenmarkEst. completion Aug 10, 2027
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iWAIST Trial: ERCG (Endoscopic Radial Compression Gastroplasty) +Optimized Lifestyle Intervention (OLI) vs Sham + OLI for Weight LossRecruiting
Overweight and/or ObesityMetabolic SyndromeNonalcoholic Fatty Liver Disease
This randomized, sham-controlled trial evaluates the efficacy and safety of ERCG plus optimized lifestyle intervention c…
Beijing, ChinaEst. completion Mar 30, 2027
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Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot StudyPhase 1Recruiting
High Blood SugarHigh Blood PressureOverweight and Obesity
Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides …
Edmonton, CanadaEst. completion Jan 2027
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Cities for Better Health Childhood Obesity Prevention Initiative in JAPANRecruiting
Quality of Life (QOL)NutritionPhysical ActivityObesityChildhood Obesity
The goal of this interventional study is to prevent childhood obesity in children aged 6-12 years in Chiba City, Japan. …
Chiba, JapanEst. completion Sep 2027
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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Two Formulations of ASC36 Injection in Participants With Obesity or OverweightPhase 1Recruiting
Chronic Weight Management
This randomized, double-blind, placebo-controlled single ascending dose (SAD)/ multiple ascending dose (MAD) study is de…
San Antonio, United StatesEst. completion Jun 2027
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A Study of SA030 Injection in Overweight or Obese ParticipantsPhase 1Recruiting
ObeseOverweight
This study is the first time SA030 is being given to people. The goal is to understand how safe it is, how well it is to…
Brisbane, AustraliaEst. completion Apr 24, 2028
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A Single Ascending Dose and Multiple Ascending Doses Study of SYH2082 Injection in Healthy ParticipantsPhase 1Recruiting
Overweight or Obesity
To evaluate the safety and tolerability of single dose and multiple doses of SYH2082 Injection in healthy participants.
Nedlands, AustraliaEst. completion Jan 30, 2027
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Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin ResistancePhase 3Recruiting
Obesity, ChildhoodInsulin Resistance
This is a 12-month, single center, three-arm parallel design, double-blind, randomized clinical trial, to compare the ef…
Edmonton, CanadaEst. completion Feb 2027
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Lean Mass Changes With Semaglutide in Adults With Type 1 Diabetes and Overweight/Obesity.Phase 2Recruiting
Type 1 DiabetesOverweight , Obesity
The goal of this 24 week double-blinded, randomized, parallel controlled clinical trial is to learn how semaglutide affe…
Montreal, CanadaEst. completion Sep 1, 2028
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Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)Phase 3Recruiting
Obesity or Overweight
Efficacy, safety and tolerability of switching from GLP-1RA to maridebart cafraglutide in adults with obesity or overwei…
Pelham, United StatesEst. completion Jan 3, 2028
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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC36 Tablets for Oral Use in Adult Participants With Obesity or OverweightPhase 1Recruiting
Chronic Weight Management
This is a randomized, placebo-controlled, double-blind, single and multiple ascending dose study to evaluate the safety,…
South Miami, United StatesEst. completion Apr 2027
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Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune ProfilesRecruiting
Obesity (BMI Equal to or >30)Immune FunctionHDLGut MicrobiomeHealthy Adult Participants
The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-…
Storrs, United StatesEst. completion Dec 31, 2027
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