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Data source: ClinicalTrials.gov
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Showing 1508 trials for Obesity & Metabolic Health
Digital Dietary Intervention for Patients Receiving GLP-1 Receptor Agonist TherapyRecruiting
Type 2 Diabetes Mellitus (T2DM)Obesity (Disorder)OverweightMetabolic Syndrome
The goal of this clinical trial is to learn whether the NutriSteppe mobile application can improve blood sugar control a…
Almaty, KazakhstanEst. completion Nov 2026
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A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With ObesityPhase 4Recruiting
Obesity & Overweight
This study investigates the Topical-Lingual (T-L) delivery of semaglutide, a GLP-1 receptor agonist (GLP-1RA), via an or…
Minneapolis, United StatesEst. completion May 2027
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Pharmacogenetics of Response to GLP1R AgonistsPhase 1Recruiting
ObesityDiabetes Type 2
Overweight/obese otherwise healthy volunteers will be recruited from the Old Order Amish population in Lancaster County,…
Lancaster, United StatesEst. completion Apr 30, 2027
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Sit Less, Interact and Move More (SLIMM) 2 StudyPhase 2Recruiting
Chronic Kidney DiseasesObesity
* Prolonged sitting (sedentary behavior) is a risk factor for decreased kidney function, obesity, diabetes and mortality…
Stanford, United StatesEst. completion Dec 31, 2026
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Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ZT003 Injection Following Single and Multiple Subcutaneous Administration in Healthy Volunteers/Overweight or Obese VolunteersPhase 1Recruiting
Healthy
This is a Phase 1, randomized, double-blind, placebo-controlled, single-center study designed to evaluate the safety, to…
Brisbane, AustraliaEst. completion Dec 24, 2026
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Long-Term Effects of Walnut Consumption on Brain FunctionRecruiting
HealthyBrain Insulin SensitivityCerebral Blood FlowBrain Vascular FunctionSatiety and Food IntakeFood RewardCognitive PerformanceAbdominal ObesityCognitive Decline
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabol…
Maastricht, NetherlandsEst. completion Aug 2027
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Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or ObesityPhase 3Recruiting
Atherosclerotic Cardiovascular DiseaseOverweightObesity
The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as …
Daphne, United StatesEst. completion Jun 30, 2028
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Prebiotic Inulin for Late-Reproductive IndividualsRecruiting
Obesity & OverweightPerimenopausal WomenPrebioticsInulinMuscle, SkeletalCardiovascular Diseases (CVD)MicrobiotaGastrointestinal MicrobiomeDietary FiberWomen HealthVascular HealthInsulin Resistance
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or …
Washington D.C., United StatesEst. completion Feb 2028
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A Study to Test How Well Different Doses of BI 3034701 Are Tolerated by Japanese Healthy People and Japanese People With Obesity or OverweightPhase 1Recruiting
HealthyObesity
Part 1: To investigate safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BI 3034701 in Japanese …
Fukuoka, Fukuoka, JapanEst. completion Dec 22, 2026
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Impact of a Perioperative Physical Exercise and Respiratory Physiotherapy Program on the Patient Undergoing Bariatric SurgeryRecruiting
Bariatric Surgery and Physical ActivityObesity/TherapyBariatric Surgery ComplicationsBariatric Patients
The goal of this clinical trial is to see the impact of a physical exercise programme and respiratory physiotherapy befo…
Vigo, SpainEst. completion Sep 30, 2028
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Transdiagnostic Intervention to Reduce Internalized Health-Related StigmaRecruiting
ObesitySkin DiseaseCancerHIVDiabetesChronic Pain
Stigma due to health conditions increases disease burden and adversely impacts health. The internalization of health-rel…
Gainesville, United StatesEst. completion Dec 31, 2026
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A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or ObesityPhase 2Recruiting
Adults With Overweight/Obesity and Type 2 Diabetes
The goal of this clinical trial is to learn if AT673 contributes to additional weight loss and glycemic control when giv…
Chandler, United StatesEst. completion Feb 2027
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Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor AgonistsRecruiting
Obesity & OverweightDiabetes (DM)
This study examines how adults who take a GLP-1 receptor agonist medication (such as semaglutide \[Ozempic, Wegovy, Rybe…
Columbus, United StatesEst. completion Oct 2026
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The NTU JO-SMART StudyRecruiting
Knee OsteoarthristisDiabetes (DM)Obesity & OverweightChronic Kidney Disease
This study recruits patients with coexisting obesity and knee osteoarthritis (KOA) to implement the NTU-JO Smart Program…
Taipei, TaiwanEst. completion Dec 31, 2029
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The Osteoarthritis Prevention StudyRecruiting
Osteoarthritis, Knee
The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss…
Boston, United StatesEst. completion Jul 31, 2029
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Physical and Behavioral Traits of Overweight and Obese AdultsRecruiting
ObesityHealthy Volunteers
This study will describe the phenotype (physical and behavioral traits) of overweight and obese people. It will characte…
Bethesda, United States
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A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or OverweightPhase 2Recruiting
ObesityOverweight
This study is open to adults between 18 and 74 years of age and who have a body mass index (BMI) of 30 kg/m2 or more, or…
Birmingham, United StatesEst. completion Aug 4, 2027
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Physical Exercise on Metabolic Health, Gut Microbiota, Physical Fitness, and Quality of Life in Obese Breast Cancer SurvivorsRecruiting
Breast Cancer Females
The goal of this clinical trial is to evaluate whether a 3-month dance-based exercise program combined with individualiz…
Bratislava, SlovakiaEst. completion Mar 1, 2026
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A Study to Evaluate ALN-6222 in Participants With ObesityPhase 1Recruiting
Obesity
This is a first in human, randomized, double-blind (DB), placebo-controlled, single ascending dose (SAD), Phase 1 study …
Mount Royal, CanadaEst. completion Dec 14, 2027
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Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related ComorbidityPhase 2Recruiting
ObesityOverweight
The primary objective of this study is to determine the efficacy of oral KAI-7535 once daily compared with placebo on pe…
Chandler, United StatesEst. completion Jul 7, 2027
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