Bacterial VaginosisVaginal MicrobiomeChlamydia Trachomatis InfectionNeisseria Gonorrheae InfectionTrichomonas Vaginitis
HIV remains a global pandemic with 37 million infected. In western Kenya, 16% of women in the general population and 29%…
Chicago, United StatesEst. completion Jul 31, 2026
Constipation
This randomized, double-blind, placebo-controlled trial will assess the clinical effects of Akk09 in adults with functio…
Suzhou, ChinaEst. completion Mar 1, 2027
Intestinal Disease
The gut microbiota plays a crucial role in human health, influencing metabolism, immunity, and pathogen resistance. Rese…
Rome, ItalyEst. completion Mar 10, 2027
Dysbiosis
This study aims to determine the effect of three factors (delivery type, feeding type and the use of two different dieta…
Sant Cugat del Vallès, SpainCompleted Mar 12, 2024
SchizophreniaSchizoaffective Disorder
The proposed project is based on the observation that schizophrenia is characterized by a chronic pro-inflammatory state…
Catonsville, United StatesEst. completion Dec 31, 2026
HealthyBrain Insulin SensitivityCerebral Blood FlowBrain Vascular FunctionSatiety and Food IntakeFood RewardCognitive PerformanceAbdominal ObesityCognitive Decline
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabol…
Maastricht, NetherlandsEst. completion Aug 2027
Extensive Stage Lung Small Cell Carcinoma
This phase II/III trial compares the effect of adding radiation therapy to the usual maintenance therapy with atezolizum…
Birmingham, United StatesEst. completion Apr 30, 2027
Osteoarthritis, Knee
The current study aims to evaluate the effectiveness of adding probiotics to the standard of care in improving OA patien…
Banī Suwayf, EgyptCompleted Feb 15, 2026
Recurrent Tonsillitis
This prospective, multicenter, randomized, double-blind, placebo-controlled, cross-over clinical trial will evaluate the…
Urbino, ItalyCompleted Jul 23, 2026
Clostridium Difficile Infection
This is a Phase 1, first-in-human, double-blind, placebo-controlled, adaptive-design, single-site study, involving dose …
Multiple LocationsEst. completion Aug 22, 2028
Low Grade AstrocytomaLow Grade GliomaMetastatic Low Grade AstrocytomaMetastatic Low Grade GliomaWHO Grade 1 GliomaWHO Grade 2 Glioma
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincr…
Birmingham, United StatesEst. completion Dec 31, 2030
Obesity & OverweightPerimenopausal WomenPrebioticsInulinMuscle, SkeletalCardiovascular Diseases (CVD)MicrobiotaGastrointestinal MicrobiomeDietary FiberWomen HealthVascular HealthInsulin Resistance
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or …
Washington D.C., United StatesEst. completion Feb 2028
Development, Child
The goal of this randomized controlled trial (RCT) is to evaluate an intestinal health-targeted nutritional intervention…
Coatepeque, GuatemalaEst. completion Jun 15, 2030
Alcohol Use DisorderAlcohol-associated Liver DiseaseAlcoholic CirrhosisHealthy
The goal of this project is to determine an individual's ability to generate active gut microbial metabolites called uro…
Louisville, United StatesEst. completion Jun 30, 2031
Oncology
The primary aim of this study is to evaluate the feasibility of a supervised high intensity interval training (HIIT) pro…
Arnhem, NetherlandsEst. completion Jul 1, 2028
Diffuse Large B Cell Lymphoma
Despite impressive outcomes in selected patients, significant heterogeneity in clinical response to CAR-T cell therapy r…
Bologna, ItalyEst. completion Jul 2027
MemoryCognitive Function
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradua…
Los Angeles, United StatesEst. completion Feb 21, 2027
ObesityDental Care for Children
The goal of this clinical trial is to assess whether adjunctive dental cleaning can enhance the effects of semaglutide i…
Lexington, United StatesEst. completion Jul 31, 2028
Breast Cancer Females
The goal of this clinical trial is to evaluate whether a 3-month dance-based exercise program combined with individualiz…
Bratislava, SlovakiaEst. completion Mar 1, 2026
Healthy Volunteers
Background:
The Laboratory of Immune System Biology (LISB) works with other labs at the National Institutes of Health. …
Bethesda, United StatesEst. completion Jun 30, 2043