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Data source: ClinicalTrials.gov
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Showing 1138 microbiome trials
Prevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell TransplantRecruiting
Hematopoietic Stem Cell Transplant
Background: Hematopoietic stem cell transplant (HSCT) is a common treatment for many cancers and other illnesses. But m…
Bethesda, United StatesEst. completion Jun 30, 2031
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A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHDPhase 2Recruiting
ADHDADHD - Attention Deficit Disorder With HyperactivityADHD - Combined Type
The primary goals of this phase 2 clinical trial are to determine the feasibility, safety, and tolerability of oral Feca…
Calgary, CanadaEst. completion Aug 31, 2028
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FMT+ QL1706+Bevacizumab+ XELOX as First-line Treatment for Advanced MSS-type Colorectal Cancer With Liver MetastasisPhase 2Recruiting
Colorectal Cancer Liver Metastasis
The investigators plan to initiate a prospective, multicenter, phase II study, recruiting 30 patients with advanced colo…
Changzhou, ChinaEst. completion Feb 1, 2027
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Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis PatientsCompleted
Amyotrophic Lateral Sclerosis
Given the role of adaptive immunity in ALS, the pathogenicity of some clostridial strains on motorneurons, the putative …
Roma, ItalyCompleted Feb 1, 2025
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Discovery and Validation of Biomarkers for CSA-AKI Risk PredictionRecruiting
CSA-AKIAcute Kidney InjuryCardiovascular SurgeryBiomarkers
This study aims to discover and validate new biomarkers for predicting CSA-AKI before cardiovascular surgery. Nested ca…
Beijing, ChinaEst. completion Jun 30, 2027
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Oral Fecal Microbiota Transplantation in Advanced Hepatocellular Carcinoma After Progression on ICI-TKI TherapyPhase 2Recruiting
Advanced Hepatocellular Carcinoma
This prospective, single-center, single-arm phase 2 study evaluates the efficacy and safety of adding oral fecal microbi…
Shenzhen, ChinaEst. completion May 20, 2027
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Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood CancersPhase 2Recruiting
Core Binding Factor Alpha SubunitsHematologic NeoplasmsLeukemiaLymphoma
Background: Some blood cancers can be caused by germline variants (changes) in a person s RUNX1 gene. Germline variants…
Bethesda, United StatesEst. completion Jun 1, 2033
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Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital AnemiasPhase 1Recruiting
Congenital Hemolytic AnemiaSickle Cell Disease
People with severe congenital anemias, such as sickle cell anemia and beta-thalassemia, have been cured with bone marrow…
Bethesda, United StatesEst. completion Jan 20, 2023
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Fecal Microbiota Transplantation for Obese Women With Polyendocrine Metabolic Ovarian SyndromeRecruiting
PCOS (Polycystic Ovary Syndrome)
This prospective, two-stage clinical trial aims to evaluate the safety, preliminary efficacy, and reproductive outcomes …
Shanghai, ChinaEst. completion Dec 31, 2028
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Standardized Microbiota Transplant Therapy in Crohn's DiseasePhase 2Recruiting
Crohn Disease
Crohn's disease (CD) develops because of a disruption of homeostasis between the gut microbiota and the host immune syst…
Minneapolis, United StatesEst. completion Jun 15, 2029
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Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family MembersENROLLING_BY_INVITATION
NeoplasmsHematologic NeoplasmsHealthy Volunteers
This study will collect biological samples for use in research experiments aimed at better understanding the clinical fe…
Bethesda, United States
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Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous DiseasePhase 1ENROLLING_BY_INVITATION
Chronic Granulomatous Disease (CGD)
Background: X-Linked Chronic Granulomatous Disease (X-CGD) is caused by a gene mutation that makes the immune system to…
Bethesda, United StatesCompleted Sep 1, 2028
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MTC Versus FMT in for RCDIPhase 1Completed
Clostridiodies Difficile Infections
Investigating four different treatment of MTC or FMT
New York, United StatesCompleted Nov 13, 2025
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An Open-Label, Pilot Clinical Trial To Test The Safety And Feasibility Of A Suspension of Freeze-dried Microbiota In Patients Undergoing Colon ResectionPhase 1Completed
Recurrent Clostridioides Difficile InfectionColonic Surgery
This Phase 1 pilot clinical trial that will evaluate the initial safety and feasibility of orally administered preparati…
Minneapolis, United StatesCompleted Jun 8, 2026
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Base-Edited Hematopoietic Stem/Progenitor Cell X-Linked Severe Combined Immunodeficiency Gene TherapyPhase 1ENROLLING_BY_INVITATION
X-linked Severe Combined ImmunodeficiencyX-SCIDXSCID
Background: X-linked severe combined immunodeficiency (XSCID) is a rare inherited disorder that affects the immune syst…
Bethesda, United StatesCompleted Dec 31, 2034
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Capsule Microbiota Transplant Therapy for Hidradenitis SuppurativaEARLY_PHASE1Recruiting
Hidradenitis Suppurativa
HS is relatively common in the United States with a prevalence of 0.1-1.0%. 1 HS has a dramatic impact on quality of lif…
Minneapolis, United StatesEst. completion Dec 30, 2026
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Intestinal Microbiota Transplantation in Patients Undergoing Colon ResectionPhase 1Recruiting
Recurrent Clostridioides Difficile InfectionColonic Surgery
This is a single-center, open-label study for safety and feasibility of IMT in patients undergoing colonic surgery. Afte…
Minneapolis, United StatesEst. completion Dec 1, 2027
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PULSAR Combined With Fecal Microbiota Transplantation for Advanced Hepatocellular Carcinoma Progressing After First-Line Targeted-ImmunotherapyPhase 2Recruiting
Hepatocellular Carcinoma (HCC)
This is an open-label, multicenter, randomized controlled Phase II trial. Patients with advanced hepatocellular carcinom…
Chengdu, ChinaEst. completion Jan 31, 2028
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High Dose Vitamin A in Preventing Gastrointestinal GVHD in Participants Undergoing Donor Stem Cell TransplantCompleted
Allogeneic Hematopoietic Stem Cell Transplantation Recipient
This phase I trial studies the side effects and how well high dose vitamin A works in preventing gastrointestinal graft …
Columbus, United StatesCompleted Apr 30, 2025
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Pilot Trial of Colchicine for Graft Failure in CABGPhase 4Recruiting
CABGGraft FailureColchicine
This is a single-center, prospective, randomized, open-label, assessor-blinded, blank-controlled exploratory (pilot) tri…
Shanghai, ChinaEst. completion Dec 2027
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