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Data source: ClinicalTrials.gov
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Showing 3121 microbiome trials
Oral Lactobacillus Crispatus Lc-G22 as Adjunctive Therapy for Vulvovaginal CandidiasisCompleted
Vulvovaginal Candidiasis
This single-center, randomized, single-blind, placebo-controlled trial aimed to evaluate the efficacy and safety of oral…
Guangzhou, ChinaCompleted Dec 15, 2023
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A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative ColitisRecruiting
Ulcerative ColitisCrohn Disease
Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiot…
Roma, ItalyEst. completion Sep 14, 2026
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Probiotic IBNI617 for Moderate to Severe Depression: A Randomized Controlled TrialRecruiting
Major Depressive Disorder (MDD)IBNI617
IBNI617 is a live biotherapeutic product(LBP). This is a randomized, double-blind, placebo-controlled, parallel-group Ph…
Shanghai, ChinaEst. completion Dec 2027
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Adults With ConstipationRecruiting
Constipation
This randomized, double-blind, placebo-controlled trial will assess the clinical effects of Akk09 in adults with functio…
Suzhou, ChinaEst. completion Mar 1, 2027
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Assessment of the Impact of Type of Probiotic, Delivery Type and Feeding Type on Baby's Microbiota After Dysbiotic DeliveryCompleted
Dysbiosis
This study aims to determine the effect of three factors (delivery type, feeding type and the use of two different dieta…
Sant Cugat del Vallès, SpainCompleted Mar 12, 2024
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Probiotic Supplements in OsteoarthritisPhase 3Completed
Osteoarthritis, Knee
The current study aims to evaluate the effectiveness of adding probiotics to the standard of care in improving OA patien…
Banī Suwayf, EgyptCompleted Feb 15, 2026
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Evaluation of the Efficacy of Streptococcus Salivarius Evol12® in the Reduction of Recurrent Adenotonsillitis in ChildrenCompleted
Recurrent Tonsillitis
This prospective, multicenter, randomized, double-blind, placebo-controlled, cross-over clinical trial will evaluate the…
Urbino, ItalyCompleted Jul 23, 2026
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A Safety Trial to Evaluate an Orally Ingested Yeast Modified to Express a Tetra-specific Anti-toxin for Clostridioides DifficilePhase 1Recruiting
Clostridium Difficile Infection
This is a Phase 1, first-in-human, double-blind, placebo-controlled, adaptive-design, single-site study, involving dose …
Multiple LocationsEst. completion Aug 22, 2028
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Butyrate Yogurt for Cancer ConstipationPhase 2Recruiting
ConstipationGastrointestinal Cancer
Constipation is a common yet underrecognized supportive care issue in cancer patients. Its consequences extend beyond ph…
Multiple LocationsEst. completion Aug 1, 2027
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Open-Label Clinical Trial Evaluating the Impact of a Multi-Strain Commensal Probiotic Dietary Supplement on Gastrointestinal Microbiota Composition, Functional Gastrointestinal Markers, and Gastrointestinal SymptomsRecruiting
GastrointestinalMicrobiota
A single-arm, open-label prospective study will be conducted evaluating the impact of 8 weeks of supplementation at the …
Richmond, United StatesEst. completion Nov 2026
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Effect of Hifas Intima Oral on Vaginal Microbiota in Healthy WomenCompleted
Vaginal MicrobiotaMicrobiotaVaginal Microbiome
The goal of this clinical trial was to learn whether the vaginal microbiota changed after healthy women aged 18 to 45 ye…
Madrid, SpainCompleted Mar 17, 2026
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Effects of the Bifidobacterium Longum BL21 on BMI, Metabolic Indicators, and Gut Microbiota in Overweight/Obese AdultsCompleted
Overweight/Obese Adults
The goal of this study is to investigate the effects of Bifidobacterium longum subspecies BL21 on BMI, metabolic indicat…
Jinnan, ChinaCompleted Jul 30, 2024
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Research on the Efficacy and Mechanism of Shouhui Tongbian Capsules in Treating Postoperative Constipation of Benign Anal and Rectal Diseases Based on Gut Microbiota AnalysisPhase 1Recruiting
Intestinal FloraAnorectal DiseasesSurgeryConstipation
The goal of this clinical trial is to evaluate whether Shouhui Tongbian Capsule can improve postoperative constipation i…
Beijing, ChinaEst. completion Dec 31, 2026
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Bacillus Subtilis and Enterococcus Faecium Probiotic Plus Lipid-Lowering Therapy for Hypertriglyceridemic Acute Pancreatitis: A Prospective RCTPhase 4Recruiting
Hypertriglyceridemic Acute PancreatitisAcute Pancreatitis, Hypertriglyceridemia-inducedHyperlipidemia
Background: Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) has become the second most common cause of acute…
Xiamen, ChinaEst. completion Jan 18, 2028
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ADHD, Gut Problems and SynbioticRecruiting
ADHDGastrointestinalEmotion Regulation Abilities
The scope of this study is to evaluate the impact of a synbiotic product (a combination of probiotic bacteria and prebio…
Multiple LocationsEst. completion Oct 31, 2027
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Probiotic Response in Periodontal DiseaseRecruiting
Periodontal Disease
Probiotics are live microorganisms that can be taken as supplements and have shown promise in playing a beneficial role …
Multiple LocationsEst. completion Nov 2027
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Effect of a Multinutrient-Optimized Infant Formula Supplemented With Human Milk Oligosaccharides on Infant Growth and Development: A Multicenter, Randomized, Controlled TrialCompleted
Healthy
This study aims to learn about a newly developed infant formula that adds two special ingredients found in breast milk (…
Beijing, ChinaCompleted Dec 16, 2025
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Sleep More, Stress Less: 90-Day Trial of Neuralli MoodRecruiting
Psychological StressSleep DisturbanceAnxiety SymptomsDepressive SymptomsOccupational Burnout
This decentralized, single-arm study evaluates the effects of 90 days of daily Neuralli Mood supplementation on perceive…
New York, United StatesEst. completion Sep 28, 2027
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Effect of Probiotics on Appetite Regulation in Adults With Overweight/ObesityRecruiting
HealthyOverweight (BMI > 25)Overweight , ObesityMaleFemaleAdultsSatiety and Food IntakeGut Microbiota Modulation
The goal of this 16-week randomised, placebo-controlled parallel study is to investigate the effect of a newly formed pr…
Maastricht, NetherlandsEst. completion Aug 18, 2029
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An Open-label, Single-arm Interventional Study to Evaluate the Safety and Efficacy of a Probiotic-containing Cream in Children With Dry SkinRecruiting
Dry Skin
The DermaKIDS study is an open-label, single-arm interventional study designed to evaluate the safety and efficacy of a …
Lisbon, PortugalEst. completion Feb 1, 2027
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