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Data source: ClinicalTrials.gov
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Showing 3161 microbiome trials
Lactobacillus Acidophilus and Inulin for Cognitive Impairment in ObesityRecruiting
Obesity (Disorder)
This randomized crossover clinical trial aims to evaluate the effect of a synbiotic containing Lactobacillus acidophilus…
Huixquilucan, MexicoEst. completion Feb 2, 2027
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Ritual Synbiotic+, a Dietary Supplement Designed to Impact Gastrointestinal Health, Mood, and Behavior in WomenCompleted
Gastrointestinal Disease Symptoms
The aim of this study is to determine how regular consumption of Synbiotic+, a dietary supplement that contains prebioti…
Fort Collins, United StatesCompleted Aug 1, 2026
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Efficacy and Safety of Saccharomyces Boulardii in Treatment of Acute Diarrhea in Children Aged 6 Months to 5 Years OldRecruiting
Acute Diarrhea
This study aimed to evaluate the effectiveness of saccharomyces-based treatment in children with acute diarrhea aged 6 m…
Can Tho, VietnamEst. completion Aug 30, 2028
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Investigating the Impact of Probiotics on Wellbeing in a CommunityCompleted
Healthy Adult
The aim of this clinical trial is to investigate whether taking probiotics can improve thinking ability and digestive sy…
Loughborough, United KingdomCompleted Feb 20, 2026
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Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical IllnessPhase 1Recruiting
Critical Illness
Patients requiring life support therapies in intensive care units are at very high risk of hospital-acquired infections.…
Calgary, CanadaEst. completion Jan 2029
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Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori InfectionPhase 2Recruiting
HELICOBACTER PYLORI INFECTIONSHelicobacter InfectionHelicobacter Pylori Gastrointestinal Tract InfectionHelicobacter Pylori Infected Patients
Helicobacter pylori is a Gram-negative, spiral-shaped bacterium that infects up to 50% of the world's population, residi…
Shibīn al Kawm, EgyptEst. completion Dec 20, 2026
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Lactobacillus Rhamnosus GG Alleviates Oral Mucositis in Patients Undergoing RadiotherapyPhase 2Completed
Oral Mucositis
Radiation therapy is a common treatment modality in the management of head and neck malignancies. However, head and neck…
Chengdu, ChinaCompleted Mar 31, 2025
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Akkermansia Muciniphila (AKK) for Radiation-Induced Skin InjuryPhase 1Recruiting
Radiation-Induced Skin Injury
This study is a multicenter, open-label, Phase I single-arm clinical trial evaluating the safety and tolerability of a t…
Chengdu, ChinaEst. completion Nov 30, 2026
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CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer TrialPhase 2Recruiting
HSIL, High Grade Squamous Intraepithelial LesionHPV-Related Squamous Cell CarcinomaAnal HSIL
This study is focused on treatment of anal high-grade squamous intraepithelial lesions (HSIL) in persons with HIV (PWH),…
San Francisco, United StatesEst. completion May 31, 2027
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Investigation of the Effects of a Multispecies Probiotic Formulation on Perennial Allergic RhinitisCompleted
Perennial Allergic Rhinitis
The goal of this clinical trial is to learn if a probiotic formulation consisting of multiple bacterial strains has a po…
Strasbourg, FranceCompleted Feb 19, 2026
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Effects of a Sugar-Based Synbiotic Product on Cardiometabolic and Intestinal Health (SUGAR-SYN BC3O)ENROLLING_BY_INVITATION
Overweight Adults
This randomized, double-blind, controlled, crossover study investigates the effects of a sugar-based synbiotic product c…
Naples, ItalyCompleted Dec 1, 2026
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The Intervention of Lactobacillus Plantarum Probiotics in Adult Autistic Spectrum DisordersRecruiting
Autism Disorder
Phase I: Post-hoc Analysis and Longitudinal Follow-up Due to the inherent difficulty in recruiting the target number of …
Taipei, TaiwanEst. completion Dec 31, 2026
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Therapeutic Potential of a Synbiotic to Improve Mental Health in Subjects With Obesity.Recruiting
Obese Patients (BMI ≥ 30 kg/m²)AnxietyDepressive Disorder
Obese individuals are a particularly vulnerable population for mental health problems, especially depression and anxiety…
Valencia, SpainEst. completion Apr 30, 2027
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Effect of Probiotic Supplements on Osteoarthritis OutcomesRecruiting
Knee Osteoarthritis
Dysbiosis of the gut microbiota is believed to contribute to the development and progression of osteoarthritis (OA), sug…
Lund, SwedenEst. completion Apr 30, 2027
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Prevention of Celiac Disease in SkåneRecruiting
Celiac Disease in Children
This study aims to investigate the impact of being on a gluten free diet the first three years of life compared to a dai…
Malmö, SwedenEst. completion Aug 2027
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R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid TumorsPhase 1Recruiting
Solid Tumor, AdultSolid TumorMelanomaBasal Cell CancerSquamous Cell CancerAdenoma
The goal of this study is determine the safety and tolerability of orally taken probiotic (R-5780) in patients currently…
Denver, United StatesEst. completion Apr 30, 2027
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Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain InjuryRecruiting
Ventilator-Associated Pneumonia (VAP)Inha'le'd
Ventilator associated pneumonia is the most common manifestation of hospital acquired infections in ICU. The incidence o…
Nanjing, ChinaEst. completion Dec 31, 2026
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Clostridium Butyricum in Stenosing Crohn's DiseasePhase 1Recruiting
Crohn Disease (CD)
Crohn's disease is a condition of unknown etiology with an immune-mediated pathogenesis. The subgroup of Crohn's disease…
Roma, ItalyEst. completion Dec 31, 2026
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A Safety Trial to Evaluate an Orally Ingested Yeast Modified to Express a Tetra-specific Anti-toxin for Clostridioides DifficilePhase 1Recruiting
Clostridium Difficile Infection
This is a Phase 1, first-in-human, double-blind, placebo-controlled, adaptive-design, single-site study, involving dose …
Multiple LocationsEst. completion Aug 22, 2028
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The Gut - PRO StudyPhase 1Recruiting
Alzheimer Disease
The purpose of this study is to assess the safety and feasibility of an oral probiotic supplement (PS) intervention in i…
Madison, United StatesEst. completion Sep 2029
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