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Data source: ClinicalTrials.gov
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Showing 1970 microbiome trials
Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical TrialRecruiting
Healthy Volunteer
Background: As people age, the cells in the pancreas that produce insulin begin to release less of this hormone, and le…
Baltimore, United StatesEst. completion Mar 31, 2027
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Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Cellular TherapyRecruiting
Multiple MyelomaLymphoma
Higher gut microbiome diversity has been associated with improved survival following autologous stem cell transplantatio…
Omaha, United StatesEst. completion Jul 2028
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Dietary Fiber to Induce Gut Microbiota-mediated Response to Immunotherapy in Melanoma.Phase 2Recruiting
Melanoma (Skin) Stage IVMelanoma (Skin Cancer)Melanoma MetastaticMelanoma AdvancedMelanoma
Previous research has shown that a higher fiber intake may have a beneficial effect on the intestinal health and improve…
Nijmegen, NetherlandsEst. completion May 1, 2028
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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)Phase 1Recruiting
Malignant Glioma
This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radi…
Birmingham, United StatesEst. completion Jun 30, 2027
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A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative ColitisRecruiting
Ulcerative ColitisCrohn Disease
Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiot…
Roma, ItalyEst. completion Sep 14, 2026
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Single-center Exploratory Study of the Intestinal Microbiota in Patients Treated for Irritable Bowel Syndrome With Predominant Constipation and Methane ProductionRecruiting
Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS), characterized by the Rome IV criteria, is a functional bowel disorder combining abdomina…
Lyon, FranceEst. completion Oct 10, 2028
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Study of Yupingfeng Powder Treating Allergic Rhinitis (AR)Phase 2Recruiting
Allergic Rhinitis
Rhinitis is broadly defined as inflammation of the nasal mucosa. It is a common disorder that affects up to 40% of the p…
Shatin, Hong KongEst. completion Dec 31, 2026
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Impact Of A Phe-Restricted Diet On Gut Health In Children With PKURecruiting
Phenylketonuria
Phenylketonuria (PKU) is an inherited disorder of phenylalanine (Phe) metabolism. The mainstay of treatment is a Phe-res…
Birmingham, United KingdomEst. completion Dec 2026
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Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized StudyPhase 2Recruiting
Healthy VolunteerWeight GainMetabolic EffectsIntegrase Strand Transfer Inhibitors
Background: People with HIV take drugs to keep the amount of virus in their body low. One type of these drugs, called i…
Bethesda, United StatesEst. completion Jan 31, 2028
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Outcomes of Outpatients in an Gut Microbiota ClinicRecruiting
Intestinal Disease
The gut microbiota plays a crucial role in human health, influencing metabolism, immunity, and pathogen resistance. Rese…
Rome, ItalyEst. completion Mar 10, 2027
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Long-Term Effects of Walnut Consumption on Brain FunctionRecruiting
HealthyBrain Insulin SensitivityCerebral Blood FlowBrain Vascular FunctionSatiety and Food IntakeFood RewardCognitive PerformanceAbdominal ObesityCognitive Decline
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabol…
Maastricht, NetherlandsEst. completion Aug 2027
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Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR TrialPhase 2Recruiting
Extensive Stage Lung Small Cell Carcinoma
This phase II/III trial compares the effect of adding radiation therapy to the usual maintenance therapy with atezolizum…
Birmingham, United StatesEst. completion Apr 30, 2027
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A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade GliomaPhase 3Recruiting
Low Grade AstrocytomaLow Grade GliomaMetastatic Low Grade AstrocytomaMetastatic Low Grade GliomaWHO Grade 1 GliomaWHO Grade 2 Glioma
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincr…
Birmingham, United StatesEst. completion Dec 31, 2030
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Prebiotic Inulin for Late-Reproductive IndividualsRecruiting
Obesity & OverweightPerimenopausal WomenPrebioticsInulinMuscle, SkeletalCardiovascular Diseases (CVD)MicrobiotaGastrointestinal MicrobiomeDietary FiberWomen HealthVascular HealthInsulin Resistance
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or …
Washington D.C., United StatesEst. completion Feb 2028
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The INICIO-Guatemala StudyRecruiting
Development, Child
The goal of this randomized controlled trial (RCT) is to evaluate an intestinal health-targeted nutritional intervention…
Coatepeque, GuatemalaEst. completion Jun 15, 2030
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Promoting Response to IMmunotherapy by Exercise in Patients With Advanced Renal Cell CarcinomaRecruiting
Oncology
The primary aim of this study is to evaluate the feasibility of a supervised high intensity interval training (HIIT) pro…
Arnhem, NetherlandsEst. completion Jul 1, 2028
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Effect of Daily Mixed Spice Consumption on Memory FunctionRecruiting
MemoryCognitive Function
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradua…
Los Angeles, United StatesEst. completion Feb 21, 2027
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Physical Exercise on Metabolic Health, Gut Microbiota, Physical Fitness, and Quality of Life in Obese Breast Cancer SurvivorsRecruiting
Breast Cancer Females
The goal of this clinical trial is to evaluate whether a 3-month dance-based exercise program combined with individualiz…
Bratislava, SlovakiaEst. completion Mar 1, 2026
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Sample Collection From Healthy Volunteers for Assay OptimizationRecruiting
Healthy Volunteers
Background: The Laboratory of Immune System Biology (LISB) works with other labs at the National Institutes of Health. …
Bethesda, United StatesEst. completion Jun 30, 2043
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Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal FemalesPhase 1Recruiting
Postmenopausal OsteoporosisGut MicrobiomeMenopause
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone densi…
Storrs, United StatesEst. completion Feb 2028
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