Obesity (Disorder)
This randomized crossover clinical trial aims to evaluate the effect of a synbiotic containing Lactobacillus acidophilus…
Huixquilucan, MexicoEst. completion Feb 2, 2027
Low Grade AstrocytomaLow Grade GliomaMetastatic Low Grade AstrocytomaMetastatic Low Grade GliomaWHO Grade 1 GliomaWHO Grade 2 Glioma
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincr…
Birmingham, United StatesEst. completion Dec 31, 2030
ObesityType2diabetesGut MicrobiotaChronic Disease
The role of intestinal microbiota is becoming ever more important in the context of obesity, type II diabetes (T2D), and…
Novara, ItalyEst. completion Jan 31, 2027
Colorectal Cancer Liver Metastasis
The investigators plan to initiate a prospective, multicenter, phase II study, recruiting 30 patients with advanced colo…
Changzhou, ChinaEst. completion Feb 1, 2027
Periprosthetic Joint Infection (PJI)Periprosthetic Knee InfectionPeriprosthetic Hip InfectionDiagnosticPrediction
Relevance and Rationale Due to the widespread development of high-tech medical care in traumatology and orthopedics for …
Moscow, RussiaEst. completion Mar 20, 2027
NAFLD
The project will study the impact of individually tailored lifestyle counselling compared to standard care on the parame…
Prague, CzechiaEst. completion Dec 2026
Malignant Glioma
This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radi…
Birmingham, United StatesEst. completion Jun 30, 2027
Preterm BirthLow Birthweight NeonatePeriodontitisGingivitisDevelopmental Delay
The ground-breaking Prevention of Prematurity and Xylitol (PPaX) cluster randomized controlled clinical trial was conduc…
Lilongwe, MalawiEst. completion Sep 30, 2030
Healthy VolunteerWeight GainMetabolic EffectsIntegrase Strand Transfer Inhibitors
Background:
People with HIV take drugs to keep the amount of virus in their body low. One type of these drugs, called i…
Bethesda, United StatesEst. completion Jan 31, 2028
Congenital Heart Disease (CHD)
The primary objective of this study is to enhance the rates of direct breast feeding (DBF) among infants with congenital…
Phoenix, United StatesEst. completion Jun 2029
Advanced Hepatocellular Carcinoma
This prospective, single-center, single-arm phase 2 study evaluates the efficacy and safety of adding oral fecal microbi…
Shenzhen, ChinaEst. completion May 20, 2027
Healthy Volunteer
Background:
As people age, the cells in the pancreas that produce insulin begin to release less of this hormone, and le…
Baltimore, United StatesEst. completion Mar 31, 2027
Sensitive Skin
The purpose of this research study is to evaluate whether a marketed moisturizing cream can improve skin barrier functio…
New York, United StatesEst. completion Dec 16, 2026
Morbid ObesityMetabolic SyndromeDiabetes MellitusHypertensionObstructive Sleep Apnea of Adult
Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivi…
Columbia, United StatesEst. completion Jul 2028
Type 1 DiabetesDiet InterventionGlucose Control
This multicenter, randomized, controlled, open-label clinical trial aims to evaluate the effects of different carbohydra…
Nanjing, ChinaEst. completion Dec 31, 2027
Weight ManagementObesityExerciseWomenGut MicrobiomeMetabolomeHealthGut Microbiota
This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopa…
Washington D.C., United StatesEst. completion Jun 1, 2027
Gall StoneGall Stones, Common Bile DuctPancreatitisAcute Cholecystitis
The goal of this prospective observational study is to explore the role of the gut microbiome in patients with gallstone…
Ashford, United KingdomEst. completion Nov 13, 2025
HELICOBACTER PYLORI INFECTIONSHelicobacter InfectionHelicobacter Pylori Gastrointestinal Tract InfectionHelicobacter Pylori Infected Patients
Helicobacter pylori is a Gram-negative, spiral-shaped bacterium that infects up to 50% of the world's population, residi…
Shibīn al Kawm, EgyptEst. completion Dec 20, 2026
Radiation-Induced Skin Injury
This study is a multicenter, open-label, Phase I single-arm clinical trial evaluating the safety and tolerability of a t…
Chengdu, ChinaEst. completion Nov 30, 2026
AppetiteObesity and Obesity-related Medical Conditions
The overall aim of this project is to study the effects of short-term high ultra-processed food intake, compared to nutr…
Gothenburg, SwedenEst. completion Dec 31, 2026