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A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors | MicrobiomeTrials
← Back to trials NCT04432584
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors Recruiting PHASE3 INTERVENTIONAL
Read the full scientific description See full eligibility requirements Trial Details Start: 2020-09-30Est. Completion: 2027-04-18
Enrollment target: 190 participantsLocations Carolinas Healthcare System, Charlotte, North Carolina, United States Nationwide Children's Hospital, Columbus, Ohio, United States Cliniques Universitaires Saint-Luc, Brussels, Belgium AZ Delta Campus Westlaan, Roeselare, Belgium Chronos Pesquisa Clinica, Taguatinga, Federal District, Brazil Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil Hospital de Clínicas de Porto Alegre X, Porto Alegre, Rio Grande do Sul, Brazil Instituto Joinvilense de Hematologia E Oncologia, Joinville, Santa Catarina, Brazil Hospital das Clínicas FMRP-USP, Ribeirão Preto, São Paulo, Brazil *X*CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo André, São Paulo, Brazil Hospital Sírio-Libanês, São Paulo, São Paulo, Brazil Hospital Paulistano, São Paulo, São Paulo, Brazil Beneficencia Portuguesa de Sao Paulo, São Paulo, Brazil Ustav hematologie a krevni transfuze, Prague, Czechia North Estonia Medical Centre Foundation, Tallinn, Estonia Hopital Claude Huriez - CHU Lille, Lille, France Other microbiome trials you might be interested in Paroxysmal Nocturnal Hemoglobinuria
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Institut Paoli Calmette, Marseille, France
Universitaetsklinikum Aachen AOeR, Aachen, Germany
ELBLANDKLINIKUM Riesa, Riesa, Germany
General Hospital of Athens LAIKO, Athens, Greece
Attikon University General Hospital, Athens, Greece
Prince of Wales Hospital, Hong Kong, Hong Kong
Semmelweis Egyetem, Budapest, Hungary
St James's Hospital, Dublin, Ireland
Azienda Unita Sanitaria Locale- Ravenna, Ravenna, Emilia-Romagna, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Lazio, Italy
Fondazione IRCCS CA? Granda Ospedale Maggiore Policlinico, Milan, Lombardy, Italy
Azienda Ospedaliera Città della Salute e della Scienza di Torino, Turin, Piedmont, Italy
Azienda Ospedaliera Universitaria Careggi, Florence, Tuscany, Italy
Fujita Health University Hospital, Aichi, Japan
Kobe University Hospital, Hyōgo, Japan
Tokushukai Takasago Seibu Hospital, Hyōgo, Japan
Ishikawa Prefectural Central Hospital, Ishikawa, Japan
Tokai University Hospital, Kanagawa, Japan
Mie University Hospital, Mie, Japan
Japanese Red Cross Society Suwa Hospital, Nagano, Japan
Nagasaki University Hospital, Nagasaki, Japan
Sasebo City General Hospital, Nagasaki, Japan
National Hospital Organization Okayama Medical Center, Okayama, Japan
The University of Osaka Hospital, Osaka, Japan
Iwate Prefectural Isawa Hospital, Ōshū, Japan
NTT Medical Center Tokyo, Tokyo, Japan
Tokyo Medical University Hospital, Tokyo, Japan
Toyama Prefectual Central Hospital, Toyama, Japan
Amsterdam UMC, Locatie AMC, Amsterdam, Netherlands
Szpital Uniwersytecki nr2 im. dr J. Biziela, Bydgoszcz, Poland
Uniwersyteckie Centrum Kliniczne, Gda?sk, Poland
Samodzielny Publiczny Szpital Kliniczny nr 1, Lublin, Poland
Pratia Poznan, Skórzewo, Poland
MTZ Clinical Research Powered by Pratia, Warsaw, Poland
Centro Hospitalar do Baixo Vouga E.P.E. - Hospital de Aveiro, Aveiro, Portugal
Centro Hospitalar do Porto - Hospital de Santo António, Porto, Portugal
King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
National University Hospital, Singapore, Singapore
Seoul National University Hospital, Seoul, South Korea
Severance Hospital, Seoul, South Korea
Samsung Medical Center, Seoul, South Korea
Ulsan University Hospital, Ulsan, South Korea
ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Complejo Hospitalario Universitario de Santiago., Santiago de Compostela, LA Coruna, Spain
Hospital U. Central de Asturias, Asturias, Principality of Asturias, Spain
Hospital de Basurto, Bilbao, Vizcaya, Spain
Hospital Universitari Vall d'Hebron, Barcelona, Spain
Hospital General Universitario Gregorio Marañon, Madrid, Spain
Hospital Regional Universitario de Malaga, Málaga, Spain
Hospital Universitario de Salamanca, Salamanca, Spain
Hospital Universitario Virgen del Rocio, Seville, Spain
Hospital Universitario de Toledo, Toledo, Spain
Hospital Universitario Miguel Servet, Zaragoza, Spain
Akademiska Sjukhuset, Uppsala, Sweden
Changhua Christian Hospital, Chang-hua, Taiwan
Hualien Tzu Chi Hospital, Hualien City, Taiwan
National Taiwan Universtiy Hospital, Taipei, Taiwan
Hacettepe University Medical Faculty; Neurology, Ankara, Turkey (Türkiye)
Gaziantep University Medical Faculty Sahinbey Educational Research Hospital; Hematology, Gaziantep, Turkey (Türkiye)
Istanbul University Istanbul Medical Faculty; Neurology, Istanbul, Turkey (Türkiye)
Marmara University Pendik Training and Research Hospital, Hematology Department, Istanbul, Turkey (Türkiye)
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