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Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study | MicrobiomeTrials
← Back to trials NCT05092958
Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study Recruiting PHASE3 INTERVENTIONAL
Read the full scientific description See full eligibility requirements Trial Details Start: 2022-06-03Est. Completion: 2029-07-15
Enrollment target: 654 participantsLocations Mayo Clinic Hospital in Arizona, Phoenix, Arizona, United States Sutter Auburn Faith Hospital, Auburn, California, United States Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, United States Palo Alto Medical Foundation-Fremont, Fremont, California, United States Memorial Medical Center, Modesto, California, United States Palo Alto Medical Foundation-Camino Division, Mountain View, California, United States Palo Alto Medical Foundation Health Care, Palo Alto, California, United States Sutter Roseville Medical Center, Roseville, California, United States Sutter Medical Center Sacramento, Sacramento, California, United States University of California Davis Comprehensive Cancer Center, Sacramento, California, United States California Pacific Medical Center-Pacific Campus, San Francisco, California, United States Palo Alto Medical Foundation-Santa Cruz, Santa Cruz, California, United States Palo Alto Medical Foundation-Sunnyvale, Sunnyvale, California, United States Sutter Solano Medical Center/Cancer Center, Vallejo, California, United States Other microbiome trials you might be interested in Localized Renal Pelvis and Ureter Urothelial Carcinoma Locally Advanced Bladder Urothelial Carcinoma Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma Locally Advanced Ureter Urothelial Carcinoma Locally Advanced Urothelial Carcinoma Stage II Bladder Urothelial Carcinoma AJCC v6 and v7 Stage II Renal Pelvis and Ureter Cancer AJCC v7 Stage II Ureter Cancer AJCC v7 Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 Stage III Renal Pelvis and Ureter Cancer AJCC v7 Stage III Ureter Cancer AJCC v7
This phase III trial studies how well pembrolizumab works in treating patients with bladder cancer that has spread into …
Birmingham, United States
Beebe South Coastal Health Campus, Millville, Delaware, United States
Helen F Graham Cancer Center, Newark, Delaware, United States
Medical Oncology Hematology Consultants PA, Newark, Delaware, United States
Beebe Health Campus, Rehoboth Beach, Delaware, United States
MedStar Washington Hospital Center, Washington D.C., District of Columbia, United States
UF Health Cancer Institute - Gainesville, Gainesville, Florida, United States
Mayo Clinic in Florida, Jacksonville, Florida, United States
Cleveland Clinic-Weston, Weston, Florida, United States
Rush-Copley Medical Center, Aurora, Illinois, United States
Advocate Good Shepherd Hospital, Barrington, Illinois, United States
Illinois CancerCare-Bloomington, Bloomington, Illinois, United States
Illinois CancerCare-Canton, Canton, Illinois, United States
Illinois CancerCare-Carthage, Carthage, Illinois, United States
Centralia Oncology Clinic, Centralia, Illinois, United States
Northwestern University, Chicago, Illinois, United States
Rush MD Anderson Cancer Center, Chicago, Illinois, United States
University of Illinois, Chicago, Illinois, United States
Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States
AMG Crystal Lake - Oncology, Crystal Lake, Illinois, United States
Carle at The Riverfront, Danville, Illinois, United States
Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois, United States
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois, United States
Illinois CancerCare-Dixon, Dixon, Illinois, United States
Advocate Good Samaritan Hospital, Downers Grove, Illinois, United States
Carle Physician Group-Effingham, Effingham, Illinois, United States
Crossroads Cancer Center, Effingham, Illinois, United States
Advocate Sherman Hospital, Elgin, Illinois, United States
Illinois CancerCare-Eureka, Eureka, Illinois, United States
Illinois CancerCare-Galesburg, Galesburg, Illinois, United States
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois, United States
Advocate South Suburban Hospital, Hazel Crest, Illinois, United States
Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois, United States
AMG Libertyville - Oncology, Libertyville, Illinois, United States
Condell Memorial Hospital, Libertyville, Illinois, United States
Illinois CancerCare-Macomb, Macomb, Illinois, United States
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois, United States
Cancer Care Center of O'Fallon, O'Fallon, Illinois, United States
Advocate Christ Medical Center, Oak Lawn, Illinois, United States
Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, United States
Advocate Lutheran General Hospital, Park Ridge, Illinois, United States
Illinois CancerCare-Pekin, Pekin, Illinois, United States
Illinois CancerCare-Peoria, Peoria, Illinois, United States
Illinois CancerCare-Peru, Peru, Illinois, United States
Illinois CancerCare-Princeton, Princeton, Illinois, United States
UW Health Carbone Cancer Center Rockford, Rockford, Illinois, United States
Memorial Hospital East, Shiloh, Illinois, United States
Southern Illinois University School of Medicine, Springfield, Illinois, United States
Springfield Clinic, Springfield, Illinois, United States
Springfield Memorial Hospital, Springfield, Illinois, United States
Carle Cancer Center, Urbana, Illinois, United States
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois, United States
Illinois CancerCare - Washington, Washington, Illinois, United States
Rush-Copley Healthcare Center, Yorkville, Illinois, United States
Northwest Cancer Center - Crown Point, Crown Point, Indiana, United States
Northwest Oncology LLC, Dyer, Indiana, United States
Northwest Cancer Center - Hobart, Hobart, Indiana, United States
Saint Mary Medical Center, Hobart, Indiana, United States
Saint Catherine Hospital, Indianapolis, Indiana, United States
The Community Hospital, Munster, Indiana, United States
Women's Diagnostic Center - Munster, Munster, Indiana, United States
Northwest Cancer Center - Valparaiso, Valparaiso, Indiana, United States
Mary Greeley Medical Center, Ames, Iowa, United States
McFarland Clinic - Ames, Ames, Iowa, United States
McFarland Clinic - Boone, Boone, Iowa, United States
McFarland Clinic - Trinity Cancer Center, Fort Dodge, Iowa, United States
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, United States
McFarland Clinic - Jefferson, Jefferson, Iowa, United States
McFarland Clinic - Marshalltown, Marshalltown, Iowa, United States
Baptist Health Louisville, Louisville, Kentucky, United States
Harold Alfond Center for Cancer Care, Augusta, Maine, United States
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan, United States
Bronson Battle Creek, Battle Creek, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan, United States
Trinity Health Medical Center - Brighton, Brighton, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan, United States
Trinity Health Medical Center - Canton, Canton, Michigan, United States
Chelsea Hospital, Chelsea, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan, United States
Hematology Oncology Consultants-Clarkston, Clarkston, Michigan, United States
Newland Medical Associates-Clarkston, Clarkston, Michigan, United States
Cancer Hematology Centers - Flint, Flint, Michigan, United States
Genesee Hematology Oncology PC, Flint, Michigan, United States
Genesys Hurley Cancer Institute, Flint, Michigan, United States
Hurley Medical Center, Flint, Michigan, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan, United States
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, United States
West Michigan Cancer Center, Kalamazoo, Michigan, United States
Beacon Kalamazoo Cancer Center, Kalamazoo, Michigan, United States
University of Michigan Health - Sparrow Lansing, Lansing, Michigan, United States
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, United States
Henry Ford Saint John Hospital - Macomb Medical, Macomb, Michigan, United States
Trinity Health Muskegon Hospital, Muskegon, Michigan, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan, United States
Hope Cancer Center, Pontiac, Michigan, United States
Michigan Healthcare Professionals Pontiac, Pontiac, Michigan, United States
Trinity Health IHA Medical Group-Alice Gustafson Center, Pontiac, Michigan, United States
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan, United States
Corewell Health Reed City Hospital, Reed City, Michigan, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan, United States
Munson Medical Center, Traverse City, Michigan, United States
University of Michigan Health - West, Wyoming, Michigan, United States
Huron Gastroenterology PC, Ypsilanti, Michigan, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan, United States
Sanford Joe Lueken Cancer Center, Bemidji, Minnesota, United States
Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States
Hennepin County Medical Center, Minneapolis, Minnesota, United States
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, United States
Regions Hospital, Saint Paul, Minnesota, United States
Rice Memorial Hospital, Willmar, Minnesota, United States
Saint Francis Medical Center, Cape Girardeau, Missouri, United States
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters, Missouri, United States
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri, United States
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri, United States
Saint Luke's Hospital of Kansas City, Kansas City, Missouri, United States
Saint Luke's East - Lee's Summit, Lee's Summit, Missouri, United States
Washington University School of Medicine, St Louis, Missouri, United States
Siteman Cancer Center-South County, St Louis, Missouri, United States
Siteman Cancer Center at Christian Hospital, St Louis, Missouri, United States
Mercy Hospital Saint Louis, St Louis, Missouri, United States
OptumCare Cancer Care at Charleston, Las Vegas, Nevada, United States
OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada, United States
New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire, United States
Solinsky Center for Cancer Care, Manchester, New Hampshire, United States
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
Memorial Sloan Kettering Monmouth, Middletown, New Jersey, United States
Memorial Sloan Kettering Bergen, Montvale, New Jersey, United States
Morristown Medical Center, Morristown, New Jersey, United States
Saint Joseph's Regional Medical Center, Paterson, New Jersey, United States
Overlook Hospital, Summit, New Jersey, United States
University of New Mexico Cancer Center, Albuquerque, New Mexico, United States
Memorial Medical Center-Las Cruces, Las Cruces, New Mexico, United States
Memorial Sloan Kettering Commack, Commack, New York, United States
Arnot Ogden Medical Center/Falck Cancer Center, Elmira, New York, United States
Glens Falls Hospital, Glens Falls, New York, United States
Memorial Sloan Kettering Westchester, Harrison, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Upstate Cancer Center at Oswego, Oswego, New York, United States
Stony Brook University Medical Center, Stony Brook, New York, United States
State University of New York Upstate Medical University, Syracuse, New York, United States
SUNY Upstate Medical Center-Community Campus, Syracuse, New York, United States
Memorial Sloan Kettering Nassau, Uniondale, New York, United States
Upstate Cancer Center at Verona, Verona, New York, United States
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina, United States
Levine Cancer Institute-SouthPark, Charlotte, North Carolina, United States
Atrium Health University City/LCI-University, Charlotte, North Carolina, United States
Levine Cancer Institute-Ballantyne, Charlotte, North Carolina, United States
Southeastern Medical Oncology Center-Clinton, Clinton, North Carolina, United States
Atrium Health Cabarrus/LCI-Concord, Concord, North Carolina, United States
Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina, United States
Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina, United States
Atrium Health Lincoln/LCI-Lincolnton, Lincolnton, North Carolina, United States
Atrium Health Cleveland/LCI-Cleveland, Shelby, North Carolina, United States
Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States
Sanford Bismarck Medical Center, Bismarck, North Dakota, United States
Sanford Broadway Medical Center, Fargo, North Dakota, United States
Sanford Roger Maris Cancer Center, Fargo, North Dakota, United States
Cleveland Clinic Akron General, Akron, Ohio, United States
Miami Valley Hospital South, Centerville, Ohio, United States
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio, United States
Cleveland Clinic Foundation, Cleveland, Ohio, United States
Premier Blood and Cancer Center, Dayton, Ohio, United States
Dayton Physician LLC - Englewood, Dayton, Ohio, United States
Miami Valley Hospital North, Dayton, Ohio, United States
Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States
Miami Valley Cancer Care and Infusion, Greenville, Ohio, United States
Kettering Medical Center, Kettering, Ohio, United States
Cleveland Clinic Cancer Center Mansfield, Mansfield, Ohio, United States
Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio, United States
North Coast Cancer Care, Sandusky, Ohio, United States
Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio, United States
Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio, United States
Upper Valley Medical Center, Troy, Ohio, United States
South Pointe Hospital, Warrensville Heights, Ohio, United States
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio, United States
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa, Oklahoma, United States
Legacy Mount Hood Medical Center, Gresham, Oregon, United States
Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon, United States
Legacy Meridian Park Hospital, Tualatin, Oregon, United States
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania, United States
Penn State Health Medical Group - Andrews Patel Hematology/Oncology East, Harrisburg, Pennsylvania, United States
Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Jefferson Methodist Hospital, Philadelphia, Pennsylvania, United States
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina, United States
Medical University of South Carolina, Charleston, South Carolina, United States
Prisma Health Cancer Institute - Easley, Easley, South Carolina, United States
Prisma Health Cancer Institute - Butternut, Greenville, South Carolina, United States
Prisma Health Cancer Institute - Faris, Greenville, South Carolina, United States
Prisma Health Greenville Memorial Hospital, Greenville, South Carolina, United States
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, United States
Prisma Health Cancer Institute - Greer, Greer, South Carolina, United States
Levine Cancer Institute-Rock Hill, Rock Hill, South Carolina, United States
Prisma Health Cancer Institute - Seneca, Seneca, South Carolina, United States
Avera Cancer Institute-Aberdeen, Aberdeen, South Dakota, United States
Rapid City Regional Hospital, Rapid City, South Dakota, United States
Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States
Avera Cancer Institute at Yankton, Yankton, South Dakota, United States
University Cancer Specialists - Alcoa, Alcoa, Tennessee, United States
University of Tennessee - Knoxville, Knoxville, Tennessee, United States
UT Southwestern Simmons Cancer Center - RedBird, Dallas, Texas, United States
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth, Texas, United States
UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas, United States
Bon Secours Memorial Regional Medical Center, Mechanicsville, Virginia, United States
Bon Secours Saint Francis Medical Center, Midlothian, Virginia, United States
Bon Secours Saint Mary's Hospital, Richmond, Virginia, United States
Virginia Cancer Institute, Richmond, Virginia, United States
VCU Massey Cancer Center at Stony Point, Richmond, Virginia, United States
VCU Massey Comprehensive Cancer Center, Richmond, Virginia, United States
VCU Community Memorial Health Center, South Hill, Virginia, United States
Shenandoah Oncology PC, Winchester, Virginia, United States
Valley Medical Center, Renton, Washington, United States
Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver, Washington, United States
Legacy Salmon Creek Hospital, Vancouver, Washington, United States
Vandalia Health/CAMC Institute for Academic Medicine, Charleston, West Virginia, United States
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin, United States
Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin, United States
Aurora Health Care Germantown Health Center, Germantown, Wisconsin, United States
Aurora Cancer Care-Grafton, Grafton, Wisconsin, United States
Aurora BayCare Medical Center, Green Bay, Wisconsin, United States
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin, United States
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin, United States
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, United States
Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin, United States
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin, United States
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, United States
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Aurora Sinai Medical Center, Milwaukee, Wisconsin, United States
Marshfield Medical Center - Minocqua, Minocqua, Wisconsin, United States
ProHealth D N Greenwald Center, Mukwonago, Wisconsin, United States
Cancer Center of Western Wisconsin, New Richmond, Wisconsin, United States
Drexel Town Square Health Center, Oak Creek, Wisconsin, United States
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States
Aurora Cancer Care-Racine, Racine, Wisconsin, United States
Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin, United States
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin, United States
Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin, United States
Aurora Medical Center in Summit, Summit, Wisconsin, United States
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin, United States
ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin, United States
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin, United States
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin, United States
Aurora West Allis Medical Center, West Allis, Wisconsin, United States
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend, Wisconsin, United States
Marshfield Medical Center - Weston, Weston, Wisconsin, United States
Cross Cancer Institute, Edmonton, Alberta, Canada
University Health Network-Princess Margaret Hospital, Toronto, Ontario, Canada
Allan Blair Cancer Centre, Regina, Saskatchewan, Canada
Saskatoon Cancer Centre, Saskatoon, Saskatchewan, Canada Est. completion Jan 1, 2027
Bladder Adenocarcinoma Bladder Clear Cell Adenocarcinoma Bladder Mixed Adenocarcinoma Bladder Neuroendocrine Carcinoma Bladder Small Cell Neuroendocrine Carcinoma Bladder Squamous Cell Carcinoma Chromophobe Renal Cell Carcinoma Collecting Duct Carcinoma Invasive Bladder Giant Cell Urothelial Carcinoma Invasive Bladder Lymphoepithelioma-Like Carcinoma Invasive Bladder Nested Urothelial Carcinoma Invasive Bladder Plasmacytoid Urothelial Carcinoma Invasive Bladder Sarcomatoid Urothelial Carcinoma Invasive Bladder Urothelial Carcinoma Kidney Medullary Carcinoma Large Cell Neuroendocrine Carcinoma Malignant Testicular Leydig Cell Tumor Malignant Testicular Sertoli Cell Tumor Metastatic Bladder Carcinoma Metastatic Bladder Clear Cell (Glycogen-Rich) Urothelial Carcinoma Metastatic Bladder Giant Cell Urothelial Carcinoma Metastatic Bladder Large Cell Neuroendocrine Carcinoma Metastatic Bladder Lipid-Rich Urothelial Carcinoma Metastatic Bladder Micropapillary Urothelial Carcinoma Metastatic Bladder Plasmacytoid Urothelial Carcinoma Metastatic Bladder Sarcomatoid Urothelial Carcinoma Metastatic Bladder Small Cell Neuroendocrine Carcinoma Metastatic Bladder Squamous Cell Carcinoma Metastatic Chromophobe Renal Cell Carcinoma Metastatic Kidney Medullary Carcinoma Metastatic Malignant Genitourinary System Neoplasm Metastatic Papillary Renal Cell Carcinoma Metastatic Penile Carcinoma Metastatic Prostate Small Cell Neuroendocrine Carcinoma Metastatic Sarcomatoid Renal Cell Carcinoma Metastatic Urethral Carcinoma Papillary Renal Cell Carcinoma Sarcomatoid Renal Cell Carcinoma Stage IV Bladder Cancer AJCC v8 Stage IV Penile Cancer AJCC v8 Stage IV Renal Cell Cancer AJCC v8 Stage IV Urethral Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8 Urachal Adenocarcinoma Urethral Clear Cell Adenocarcinoma
This phase II trial studies how well cabozantinib works in combination with nivolumab and ipilimumab in treating patient…
Birmingham, United States Est. completion Feb 28, 2027