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A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | MicrobiomeTrials
← Back to trials NCT06973187
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Recruiting PHASE3 INTERVENTIONAL
Read the full scientific description See full eligibility requirements Trial Details Start: 2025-09-04Est. Completion: 2028-04-17
Enrollment target: 500 participantsLocations University of Alabama At Birmingham Hospital, Birmingham, Alabama, United States Mayo Clinic Phoenix, Phoenix, Arizona, United States Kaiser Permanente Southern California, Irvine, California, United States University of California San Diego (Ucsd) Moores Cancer Center, La Jolla, California, United States Cancer and Blood Specialty Clinic, Los Alamitos, California, United States UCLA Department of Medicine Hematologyoncology, Los Angeles, California, United States Kaiser Permanente Oakland Medical Center, Oakland, California, United States Stanford Cancer Institute, Palo Alto, California, United States Kaiser Permanente Roseville Medical Center, Roseville, California, United States Kaiser Permanente San Francisco Medical Center Oncology, San Francisco, California, United States Kaiser Permanente Santa Clara Medical Center Oncologyhematology, Santa Clara, California, United States Kaiser Permanente Northern California, Vallejo, California, United States Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, California, United States Christiana Care, Newark, Delaware, United States Other microbiome trials you might be interested in Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma
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Medstar Georgetown University Hospital, Washington D.C., District of Columbia, United States
Mayo Clinic Jacksonville, Jacksonville, Florida, United States
Cancer Specialists of North Florida, Jacksonville, Florida, United States
Mount Sinai Medical Center Braman Comprehensive Cancer Center, Miami, Florida, United States
University of Chicago Medical Center, Chicago, Illinois, United States
Mission Cancer and Blood, Waukee, Iowa, United States
The University of Kansas Cancer Center, Westwood, Kansas, United States
Our Lady of the Lake Hospital, Baton Rouge, Louisiana, United States
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, United States
Ochsner Clinic Foundation, New Orleans, Louisiana, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Karmanos Cancer Institute, Detroit, Michigan, United States
Mayo Clinic Rochester, Rochester, Minnesota, United States
Washington University School of Medicine, St Louis, Missouri, United States
Titan Health Partners Llc Dba Astera Cancer Care, East Brunswick, New Jersey, United States
John Theurer Cancer Center Hackensack University Medical Center, Hackensack, New Jersey, United States
Columbia University Medical Center, New York, New York, United States
Weill Cornell Medical College Newyork Presbyterian Hospital, New York, New York, United States
Memorial Sloan Kettering Cancer Center Mskcc, New York, New York, United States
University of Rochester, Rochester, New York, United States
University of North Carolina At Chapel Hill, Chapel Hill, North Carolina, United States
Atrium Health Levine Cancer Institute (Lci), Charlotte, North Carolina, United States
Duke University Medical Center, Durham, North Carolina, United States
Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, United States
Dayton Physician Network, Dayton, Ohio, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Tennessee Oncology, Pllc Nashville, Nashville, Tennessee, United States
Md Anderson Cancer Center, Houston, Texas, United States
Blue Ridge Cancer Care (Oncology and Hematology Associates of Southwest Virginia), Roanake, Virginia, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Summit Cancer Centers, Spokane, Washington, United States
Northwest Medical Specialties, Tacoma, Washington, United States
Gunderson Health System, La Crosse, Wisconsin, United States
FUNDALEU, Caba, Argentina
Sanatorio Allende, Córdoba, Argentina
Centro Oncologico de Integracion Regional (Coir), Mendoza, Argentina
Hospital Privado de Rosario, Rosario, Argentina
Concord Repatriation General Hospital, Concord, New South Wales, Australia
St George Private Hospital, Kogarah, New South Wales, Australia
Westmead Private Hospital, Westmead, New South Wales, Australia
Pindara Private Hospital, Benowa, Queensland, Australia
Sunshine Coast Hospital and Health Service, Birtinya, Queensland, Australia
John Flynn Private Hospital, Tugun, Queensland, Australia
Flinders Medical Centre, Bedford PK, South Australia, Australia
St Vincents Hospital Melbourne, Fitzroy, Victoria, Australia
Peninsula Private Hospital, Frankston, Victoria, Australia
Austin Health, Heidelberg, Victoria, Australia
Cabrini Hospital Malvern, Malvern, Victoria, Australia
Peter Maccallum Cancer Centre, Melbourne, Victoria, Australia
The Alfred Hospital, Melbourne, Victoria, Australia
Linear Clinical Research, Nedlands, Western Australia, Australia
Medical University Graz, Graz, Austria
Medizinische Universitatsklinik Innsbruck, Innsbruck, Austria
Ordensklinikum Linz Gmbh Elisabethinen, Linz, Austria
Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg, Salzburg, Austria
Uk St Poelten, Sankt Pölten, Austria
Institut Jules Bordet, Anderlecht, Belgium
UZ GENT, Ghent, Belgium
Az Groeninge Campus Loofstraat, Kortrijk, Belgium
Chc Montlegia, Liège, Belgium
Chu de Liege, Liège, Belgium
Az Sint Maarten, Mechelen, Belgium
Chu Ucl Namur, Yvoir, Belgium
Centro de Pesquisa Clinica Dom Bosco Ltda, Araçatuba, Brazil
Hospital Felicio Rocho, Belo Horizonte, Brazil
Ictr Instituto Do Cancer E Transplante de Curitiba, Curitiba, Brazil
Hospital de Clinicas de Goiania Ufg, Goiânia, Brazil
Inca Instituto Nacional de Cancer, Rio de Janeiro, Brazil
Ensino E Terapia de Inovacao Clinica Amo Etica, Salvador, Brazil
Hospital Nove de Julho Dasa, São Paulo, Brazil
Hcfmusp Hospital Das Clinicas Da Faculdade de Medicina Da Universidade de Sao Paulo, São Paulo, Brazil
Peking Union Medical College Hospital, Beijing, Beijing Municipality, China
Fujian Medical University Union Hospital, Fuzhou, Fujian, China
The First Hospital of Lanzhou University, Lanzhou, Gansu, China
Sun Yat Sen University Cancer Center, Guangzhou, Guangdong, China
Jiangmen Central Hospital, Jiangmen, Guangdong, China
The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
Guizhou Provincial Peoples Hospital, Guiyang, Guizhou, China
The Fourth Hospital of Hebei Medical University East Branch, Shijiazhuang, Hebei, China
The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Xuchang Central Hospitalluminghu Branch, Xuchang, Henan, China
Henan Cancer Hospital, Zhengzhou, Henan, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technologychegu Branch, Wuhan, Hubei, China
Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Wuxi Peoples Hospital, Wuxi, Jiangsu, China
The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
The First Hospital of Jilin University, Changchun, Jilin, China
The Second Hospital of Dalian Medical University, Dalian, Liaoning, China
Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Qinghai University Affiliated Hospital, Xining, Qinghai, China
The Second Affiliated Hospital of Xian Jiaotong University, Xi'an, Shaanxi, China
Binzhou Medical University Hospital, Binzhou, Shandong, China
Taian City Central Hospital, Taian, Shandong, China
Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai Municipality, China
Shanxi Bethune Hospital, Taiyuan, Shanxi, China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu, Sichuan, China
Dazhou Central Hospital, Dazhou, Sichuan, China
The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Institute of Hematology and Hospital of Blood Disease, Tianjin, Tianjin Municipality, China
First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux, France
Hopital Estaing, ClermontFerrand, France
Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes, France
Hopital Saint Louis, Paris, France
Centre Henri Becquerel, Rouen, France
Iuc Toulouse Oncopole, Toulouse, France
Chu Tours Hopital Bretonneau, Tours, France
Chu Nancy Hopital Brabois, VandoeuvrelesNancy, France
St Josef Hospital Klinikum Der Ruhr Universitat Bochum, Bochum, Germany
Universitatsklinikum Bonn, Bonn, Germany
Uniklinik Koeln (Aoer), Cologne, Germany
Gemeinschaftspraxis Fur Hamatologie Und Onkologie Dortmund, Dortmund, Germany
Stadtisches Klinikum Karlsruhe, Karlsruhe, Germany
Mvz Fur Hamatologie Und Onkologie Lubeckgmbh, Lübeck, Germany
Robert Bosch Krankenhaus, Abteilung Hamatologie, Onkologie Und Palliativmedizin, Stuttgart, Germany
Universitaetsklinikum Ulm, Ulm, Germany
Gemeinschaftspraxis Fuer Haematologie Und Onkologie Westerstede, Westerstede, Germany
Bnai Zion Medical Center, Haifa, Israel
Shaare Zedek Medical Center, Jerusalem, Israel
Hadassah University Hospital Ein Kerem, Jerusalem, Israel
Meir Medical Center, KfarSava, Israel
Rabin Medical Center, Petah Tikva, Israel
Sheba Medical Center, Ramat Gan, Israel
Sourasky Tel Aviv Medical Center, Tel Aviv, Israel
Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna, Italy
Ospedale San Raffaele, Milan, Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy
Azienda Ospedaliera Di Padova, Padova, Italy
Aichi Cancer Center Hospital Clinical Oncology, Nagoya, Aichi-ken, Japan
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nakamuraku, Aichi-ken, Japan
Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan
Fukushima Medical University Hospital, Fukushima, Fukushima, Japan
Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Hiroshima, Japan
Aiiku Hospital, Sapporo, Hokkaido, Japan
Kochi Medical School Hospital, Nankoku, Kochi, Japan
Kumamoto University Hospital, Kumamoto, Kumamoto, Japan
Japanese Red Cross Kyoto Daini Hospital, Kyotoshi, Kyoto, Japan
Oita Prefectural Hospital, Ōita, Oita Prefecture, Japan
Okayama University Hospital, Okayama, Okayama-ken, Japan
Osaka Metropolitan University Hospital, Osaka, Osaka, Japan
Kindai University Hospital, Sakai, Osaka, Japan
Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan
Tokyo Metropolitan Komagome Hospital, Bunkyoku, Tokyo, Japan
Cancer Institute Hospital of Jfcr, Kotoku, Tokyo, Japan
National Hospital Organization (Nho) Disaster Medical Center, Tachikawashi, Tokyo, Japan
Yamagata University Hospital, Yamagata, Yamagata, Japan
Centro de Investigacion Clinica Gramel, México, Mexico
Christus Latam Hub Center of Excellence and Innovation Sc, Monterrey, Mexico
Centro de Investigacion Clinica de Oaxaca, Oaxaca City, Mexico
Centro Hemato Oncologico Privado de Toluca, Toluca, Mexico
Albert Schweitzer Ziekenhuis, Dordrecht, Netherlands
Catharina Hospital, EJ Eindhoven, Netherlands
Groene Hart Hospital, Gouda, Netherlands
University of Medical Center Groningen (Umcg), Groningen, Netherlands
Canisius Wilhelmina Ziekenhuis, Nijmegen, Netherlands
Universitair Medisch Centrum Utrecht, Utrecht, Netherlands
North Shore Hospital, Auckland, New Zealand
Tauranga Hospital, Tauranga, New Zealand
Wellington Regional Hospital (Ccdhb), Wellington, New Zealand
Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii, Gdansk, Poland
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Kielcach, Kielce, Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz, Poland
Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie, Lublin, Poland
Szpital Kliniczny Mswia Z Warmisko Mazurskim Centrum Onkologii, Olsztyn, Poland
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu, Torun, Poland
Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie W Warszawie, Warsaw, Poland
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu, Wroclaw, Poland
Auxilio Mutuo Cancer Center, San Juan, Puerto Rico
Coltea Clinical Hospital, Bucharest, Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca, ClujNapoca, Romania
Institutul Regional de Oncologie Iasi, Iași, Romania
Singapore General Hospital, Singapore, Singapore
Tan Tock Seng Hospital Haematology, Singapore, Singapore
Pusan National University Hospital, Seogu, Busan Gwang'Yeogsi, South Korea
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea
Gyeongsang National University Hospital, Jinju, Gyeongsangnam-do, South Korea
The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu, Seoul Teugbyeolsi, South Korea
Severance Hospital Yonsei University Health System, SeodaemunGu, Seoul Teugbyeolsi, South Korea
Seoul National University Hospital, Seoul, Seoul Teugbyeolsi, South Korea
Ico Badalona, Badalona, Spain
Hospital Universitario de Burgos, Burgos, Spain
Hospital Universitario de Gran Canaria Dr Negrin, Las Palmas de Gran Canaria, Spain
Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Spain
Hospital Universitari Son Espases, Palma de Mallorca, Spain
Hospital Universitario Virgen Del Rocio, Seville, Spain
Sahlgrenska Universitetssjukhuset, Gothenburg, Sweden
Karolinska Universitetssjukhuset Solna, Stockholm, Sweden
Inselspital Bern (Inselspital, Universitatsspital Bern), Bern, Switzerland
Universitatsspital Zurich, Zurich, Switzerland
University Hospitals Sussex Nhs Foundation Trust, Brighton, United Kingdom
Kent and Canterbury Hospital, Canterbury, United Kingdom
Norfolk and Norwich University Hospitals Nhs Foundation Trust, Norwich, United Kingdom
Oxford University Hospitals Nhs Foundation Trust, Oxford, United Kingdom
Spire Leeds Healthcare Spire Leeds Hospital, Roundhay, United Kingdom
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