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Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer | MicrobiomeTrials
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Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer Recruiting PHASE1, PHASE2 INTERVENTIONAL
Read the full scientific description See full eligibility requirements Trial Details Start: 2026-02-10Est. Completion: 2027-11-02
Enrollment target: 224 participantsLocations Mayo Clinic Building- Phoenix, Phoenix, Arizona, United States Mayo Clinic, Scottsdale, Arizona, United States Highlands Oncology Group, Fayetteville, Arkansas, United States Highlands Oncology Group, Rogers, Arkansas, United States Highlands Oncology Group, Springdale, Arkansas, United States City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte, California, United States City of Hope Investigational Drug Services (IDS), Duarte, California, United States UC San Diego Medical Center - Encinitas, Encinitas, California, United States City of Hope Investigational Drug Services (IDS), Irvine, California, United States City of Hope, Irvine, California, United States UC San Diego / Moores Cancer Center, La Jolla, California, United States UC San Diego Koman Family Outpatient Pavilion, La Jolla, California, United States UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion), La Jolla, California, United States UC San Diego Sulpizio Cardiovascular Center, La Jolla, California, United States Other microbiome trials you might be interested in Liver Cancer (Primary and Metastatic) Lung Cancer (Diagnosis) Bone Cancer Metastatic Bone Cancer Tumor Kidney Tumors Renal Cancer Hepatocellular Carcinoma (HCC) Renal Cell Carcinoma (Kidney Cancer) Renal Cell Carcinoma (RCC) Musculoskeletal Cancers Musculoskeletal Tumors Bone Tumors Lung Tumors
This study collects data from patients undergoing minimally invasive, image-guided cancer treatments at participating ho…
Lyon, France Est. completion Dec 31, 2030
City of Hope, Long Beach, California, United States
UC San Diego Medical Center - Bankers Hill, San Diego, California, United States
UC San Diego McGrath Outpatient Pavilion - Hillcrest, San Diego, California, United States
UC San Diego Medical Center - Hillcrest, San Diego, California, United States
UC San Diego Medical Center - Rancho Bernardo, San Diego, California, United States
City of Hope UPLAND, Upland, California, United States
UC San Diego Medical Center - Vista, Vista, California, United States
Rocky Mountain Cancer Centers, LLP, Denver, Colorado, United States
Mayo Clinic Pharmacy, Jacksonville, Florida, United States
Tennessee Oncology, PLLC- Ringgold, Ringgold, Georgia, United States
City Of Hope - Chicago, Zion, Illinois, United States
Brigham and Women's Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Dana-Farber Cancer Institute - Chestnut Hill, Newton, Massachusetts, United States
Minnesota Oncology Hematology, P.A., Burnsville, Minnesota, United States
Minnesota Oncology Hematology, P.A., Chaska, Minnesota, United States
Minnesota Oncology Hematology, P.A., Coon Rapids, Minnesota, United States
Minnesota Oncology Hematology, P.A., Edina, Minnesota, United States
Minnesota Oncology Hematology, P.A., Maple Grove, Minnesota, United States
Minnesota Oncology Hematology, P.A., Maplewood, Minnesota, United States
Mayo Clinic Hospital, Methodist Campus, Research Pharmacy, Rochester, Minnesota, United States
Mayo Clinic Cancer Center Outpatient Pharmacy, Rochester, Minnesota, United States
Minnesota Oncology Hematology, P.A., Woodbury, Minnesota, United States
MSK Basking Ridge, Basking Ridge, New Jersey, United States
MSK Monmouth, Middletown, New Jersey, United States
MSK Bergen, Montvale, New Jersey, United States
New York Oncology Hematology, P.C., Albany, New York, United States
New York Oncology Hematology - Clifton Park Cancer Center, Clifton Park, New York, United States
MSK Commack, Commack, New York, United States
MSK Westchester, Harrison, New York, United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy, Long Island City, New York, United States
Evelyn H. Lauder Breast and Imaging Center (BAIC), New York, New York, United States
Memorial Sloan Kettering Cancer Center - Main Campus, New York, New York, United States
Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center, New York, New York, United States
MSK Nassau, Uniondale, New York, United States
Grand Strand Medical Center, Myrtle Beach, South Carolina, United States
Carolina Urologic Research Center, LLC, Myrtle Beach, South Carolina, United States
Parkway Surgery Center, Myrtle Beach, South Carolina, United States
Tennessee Oncology, PLLC- Chattanooga Downtown, Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Chattanooga Med Park II, Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Chattanooga Memorial, Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC - Investigational Drug Services/Supply Storage, Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC- Chattanooga East, Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC- Cookeville, Cookeville, Tennessee, United States
Tennessee Oncology, PLLC-Dickson, Dickson, Tennessee, United States
Tennessee Oncology, PLLC- Franklin Proton Center, Franklin, Tennessee, United States
Tennessee Oncology, PLLC-Franklin, Franklin, Tennessee, United States
Tennessee Oncology, PLLC-Gallatin, Gallatin, Tennessee, United States
Tennessee Oncology, PLLC-Hendersonville, Hendersonville, Tennessee, United States
Tennessee Oncology, PLLC-Lebanon, Lebanon, Tennessee, United States
Tennessee Oncology, PLLC-Mount Juliet, Mount Juliet, Tennessee, United States
Tennessee Oncology, PLLC-Murfreesboro, Murfreesboro, Tennessee, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
SCRI Oncology Partners, Nashville, Tennessee, United States
Tennessee Oncology, PLLC- Elliston Place Plaza, Nashville, Tennessee, United States
Tennessee Oncology, PLLC-Elliston Place Plaza Medical Oncology &Hematology, Nashville, Tennessee, United States
Tennessee Oncology, PLLC-Investigational Drug Services, Nashville, Tennessee, United States
Tennessee Oncology, PLLC- Saint Thomas West, Nashville, Tennessee, United States
Tennessee Oncology, PLLC- Skyline, Nashville, Tennessee, United States
Tennessee Oncology, PLLC- Southern Hills, Nashville, Tennessee, United States
Tennessee Oncology, PLLC- Shelbyville, Shelbyville, Tennessee, United States
Tennessee Oncology, PLLC- Smyrna, Smyrna, Tennessee, United States
Texas Oncology - Central South, Austin, Texas, United States
Texas Oncology - Central South, Austin, Texas, United States
Texas Oncology - Central South, Austin, Texas, United States
Texas Oncology - Central South, Austin, Texas, United States
Texas Oncology - Gulf Coast, Beaumont, Texas, United States
Texas Oncology - Central South, Harlingen, Texas, United States
Texas Oncology - Gulf Coast, Houston, Texas, United States
Texas Oncology - Gulf Coast, Houston, Texas, United States
US Oncology Investigational Products Center (IPC), Irving, Texas, United States
US Oncology Investigational Products Center, Irving, Texas, United States
Texas Oncology - Central South, McAllen, Texas, United States
Texas Oncology - Gulf Coast, Pearland, Texas, United States
Texas Oncology - Gulf Coast, Sugar Land, Texas, United States
Texas Oncology - Gulf Coast, The Woodlands, Texas, United States
Texas Oncology - Central South, Waco, Texas, United States
Texas Oncology - Gulf Coast, Webster, Texas, United States
Texas Oncology - Central South, Weslaco, Texas, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care, Blacksburg, Virginia, United States
Virginia Cancer Specialists, PC, Fairfax, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care, Low Moor, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care, Roanoke, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care, Salem, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care, Wytheville, Virginia, United States
Northwest Cancer Specialists, P.C., Vancouver, Washington, United States
Minnesota Oncology Hematology, P.A., Hudson, Wisconsin, United States
Icon Cancer Centre Wesley, Auchenflower, Queensland, Australia
Beijing Cancer hospital, Beijing, Beijing Municipality, China
Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
The University of Osaka Hospital, Suita, Osaka, Japan
Keio university hospital, Shinjuku-ku, Tokyo, Japan
National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan
Yamagata University Hospital, Yamagata, Japan
Hospital Universitario 12 de Octubre, Madrid, Spain Phase 1
Recruiting
Head and Neck Tumors Kidney Cancers Small Cell Lung Cancers Pheochromocytoma/Paragangliomas Gastrointestinal Neuroendocrine Tumors Somatostatin Receptor Positive
Background:
Some cancers have high levels of proteins called somatostatin receptors (SSTRs) on the surface of the tumor…
Bethesda, United States Est. completion Jan 1, 2029
Advanced Esophageal Squamous Cell Carcinoma Advanced Renal Cell Carcinoma Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8 Clinical Stage IIB Cutaneous Melanoma AJCC v8 Clinical Stage IIC Cutaneous Melanoma AJCC v8 Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Clinical Stage IV Esophageal Squamous Cell Carcinoma AJCC v8 Esophageal Carcinoma Gastroesophageal Junction Adenocarcinoma Hepatocellular Carcinoma Locally Advanced Urothelial Carcinoma Lung Non-Small Cell Carcinoma Malignant Solid Neoplasm Metastatic Colorectal Carcinoma Metastatic Cutaneous Melanoma Metastatic Esophageal Squamous Cell Carcinoma Metastatic Head and Neck Squamous Cell Carcinoma Metastatic Urothelial Carcinoma Recurrent Esophageal Squamous Cell Carcinoma Recurrent Head and Neck Squamous Cell Carcinoma Renal Cell Carcinoma Stage III Renal Cell Cancer AJCC v8 Stage IV Colorectal Cancer AJCC v8 Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 Stage IV Renal Cell Cancer AJCC v8 Unresectable Cutaneous Melanoma Unresectable Esophageal Squamous Cell Carcinoma Urothelial Carcinoma Unresectable Urothelial Carcinoma
This phase II trial compares the impact of subcutaneous (SC) nivolumab given in an in-home setting to an in-clinic setti…
Jacksonville, United States Est. completion Dec 31, 2026