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Home/Conditions/Autism Spectrum & the Gut
Condition Guide

Autism Spectrum & the Gut

Exploring the gut-brain link in autism

Up to 70% of people with autism experience GI symptoms, and researchers are uncovering profound differences in gut microbiome composition. Microbiome therapies targeting autism are among the most closely watched trials in the field.

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The Microbiome Connection

How Autism Spectrum & the Gut relates to gut health

Common Symptoms

  • GI symptoms (constipation, diarrhea)
  • Abdominal pain
  • Food selectivity and sensory sensitivities
  • Behavioral changes linked to GI discomfort

How the Microbiome is Involved

Multiple studies have found that children with autism have significantly altered gut microbiomes — including lower Prevotella, Coprococcus, and Unclassified Veillonellaceae. These bacteria help produce short-chain fatty acids that support brain function and reduce neuroinflammation. The gut-brain connection in autism is an active, fast-moving area of research with parent communities closely watching trial outcomes.

Active Trials

View all 358 trials
Clinical Trial of "Exploradores de Sabores" to Improve Food Selectivity in ASD KidsRecruiting
Autism Spectrum DisorderFood Selectivity
The goal of this randomized, single-blind clinical trial is to evaluate the effectiveness of the Exploradores de Sabores…
Tijuana, MexicoEst. completion Dec 2026
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Studying Childhood-onset Behavioral, Psychiatric, and Developmental DisordersRecruiting
Neuropsychiatric DisorderNeurological DisorderNeurodevelopmental DisorderSleep
Background: \- Many psychiatric, behavioral, and developmental disorders are genetic. This means that they tend to run …
Bethesda, United StatesEst. completion Feb 20, 2029
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Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental DisordersPhase 2Recruiting
Neurodevelopmental DisordersAutismAutism Spectrum DisorderFragile X SyndromeTuberous Sclerosis22Q11 Deletion Syndrome22Q11 DeletionADHDTic DisordersTourette SyndromeTourette Syndrome in ChildrenTourette Syndrome in AdolescenceADHD - Combined TypeADHD Predominantly Inattentive TypeADHD, Predominantly Hyperactive - ImpulsiveAnxietyAnxiety Disorders
There are currently no approved medications for the treatment of anxiety in children and youth with neurodevelopmental d…
Calgary, CanadaEst. completion Sep 2027
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When good bacteria end up in the wrong place
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