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Home/Conditions/Autism Spectrum & the Gut
Condition Guide

Autism Spectrum & the Gut

Exploring the gut-brain link in autism

Up to 70% of people with autism experience GI symptoms, and researchers are uncovering profound differences in gut microbiome composition. Microbiome therapies targeting autism are among the most closely watched trials in the field.

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The Microbiome Connection

How Autism Spectrum & the Gut relates to gut health

Common Symptoms

  • GI symptoms (constipation, diarrhea)
  • Abdominal pain
  • Food selectivity and sensory sensitivities
  • Behavioral changes linked to GI discomfort

How the Microbiome is Involved

Multiple studies have found that children with autism have significantly altered gut microbiomes — including lower Prevotella, Coprococcus, and Unclassified Veillonellaceae. These bacteria help produce short-chain fatty acids that support brain function and reduce neuroinflammation. The gut-brain connection in autism is an active, fast-moving area of research with parent communities closely watching trial outcomes.

Active Trials

View all 351 trials
Behavioral Activation for Treatment of Depression in Autistic Adolescents With Below Average IntelligenceRecruiting
AutismDepressedDepressed Mood
Autism spectrum disorder is characterized by differences in social communication/interaction and the presence of restric…
Stony Brook, United StatesEst. completion Sep 2027
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Pai.ACT - An Artificial Intelligence Driven Chatbot Assisted ACT (Full Scale RCT)Recruiting
Neurodevelopmental DisordersAutism Spectrum Disorder (ASD)Attention Deficit Disorder With Hyperactivity (ADHD)
Interventions for parents of children with NDD face two pivotal challenges. Firstly, many overlook the consequential inf…
Hong Kong, Hong KongEst. completion Dec 31, 2027
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Structured Sensory-Based Occupational Therapy in Children With AutismRecruiting
Autism Spectrum Disorder
This controlled clinical study will investigate the effects of a 12-week structured sensory-based occupational therapy i…
Istanbul, Turkey (Türkiye)Est. completion Nov 1, 2026
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When good bacteria end up in the wrong place
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