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Home/Conditions/Autism Spectrum & the Gut
Condition Guide

Autism Spectrum & the Gut

Exploring the gut-brain link in autism

Up to 70% of people with autism experience GI symptoms, and researchers are uncovering profound differences in gut microbiome composition. Microbiome therapies targeting autism are among the most closely watched trials in the field.

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The Microbiome Connection

How Autism Spectrum & the Gut relates to gut health

Common Symptoms

  • GI symptoms (constipation, diarrhea)
  • Abdominal pain
  • Food selectivity and sensory sensitivities
  • Behavioral changes linked to GI discomfort

How the Microbiome is Involved

Multiple studies have found that children with autism have significantly altered gut microbiomes — including lower Prevotella, Coprococcus, and Unclassified Veillonellaceae. These bacteria help produce short-chain fatty acids that support brain function and reduce neuroinflammation. The gut-brain connection in autism is an active, fast-moving area of research with parent communities closely watching trial outcomes.

Active Trials

View all 348 trials
Coaching and Leadership in Autism Support SettingsRecruiting
Autism Spectrum Disorder (ASD)
Schools serve a large number of autistic children, yet face two critical gaps that stifle the delivery of evidence-based…
Los Angeles, United StatesEst. completion Jun 30, 2030
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AWARE: Management of ADHD in Autism Spectrum DisorderPhase 4Recruiting
ADHDAutism Spectrum Disorder
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphe…
Irvine, United StatesEst. completion Jan 1, 2027
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Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for AutismPhase 1Recruiting
Autism
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or pla…
Naples, United StatesEst. completion Dec 1, 2027
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Small Intestinal Bacterial Overgrowth (SIBO)
When good bacteria end up in the wrong place
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