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Home/Conditions/Mental Health & Gut-Brain Axis
Condition Guide

Mental Health & Gut-Brain Axis

The surprising conversation between your gut and your brain

Up to 95% of serotonin is made in the gut. The gut-brain axis is a two-way communication highway that influences mood, anxiety, and cognitive function. Microbiome research in mental health is one of the most exciting frontiers in medicine.

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The Microbiome Connection

How Mental Health & Gut-Brain Axis relates to gut health

Common Symptoms

  • Anxiety and depression
  • Brain fog and poor concentration
  • Sleep disturbances
  • IBS co-occurring with mood disorders
  • Chronic stress
  • Fatigue

How the Microbiome is Involved

Your gut microbiome produces neurotransmitters, regulates the vagus nerve, and shapes the immune signals that affect brain function. People with depression and anxiety show measurably different microbiome compositions. Psychobiotics — probiotics specifically formulated to affect mental health — are showing early promise in clinical trials for anxiety and mild depression.

Active Trials

View all 194 trials
Supporting Mental Health and Reducing Care Stress in Caregivers of Persons With Cardiovascular DiseaseRecruiting
Caregiver BurdenStressDepressionAnxietyCardiovascular Diseases
The purpose of this study is to evaluate the preliminary efficacy, feasibility, acceptability, and barriers and facilita…
Sacramento, United StatesEst. completion Jul 2027
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Enhancing Engagement by Integrating Goals and Concerns That Matter to PatientsRecruiting
Anxiety DisordersDepression Disorders
The goal of this clinical trial is to learn if adding patients' goals and concerns to measurement-based collaborative ca…
Concord, United StatesEst. completion Jul 31, 2027
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Promoting Mental Health of Teachers and Caregiver Using a Personalized mHealth Toolkit in UgandaRecruiting
Mental Health LiteracyDepression, Anxiety
This study record describes a two-phase of clinical trial study. The first phase is a pilot study phase (to study feasib…
Kampala, UgandaEst. completion Aug 1, 2027
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When good bacteria end up in the wrong place
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