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Home/Conditions/Mental Health & Gut-Brain Axis
Condition Guide

Mental Health & Gut-Brain Axis

The surprising conversation between your gut and your brain

Up to 95% of serotonin is made in the gut. The gut-brain axis is a two-way communication highway that influences mood, anxiety, and cognitive function. Microbiome research in mental health is one of the most exciting frontiers in medicine.

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The Microbiome Connection

How Mental Health & Gut-Brain Axis relates to gut health

Common Symptoms

  • Anxiety and depression
  • Brain fog and poor concentration
  • Sleep disturbances
  • IBS co-occurring with mood disorders
  • Chronic stress
  • Fatigue

How the Microbiome is Involved

Your gut microbiome produces neurotransmitters, regulates the vagus nerve, and shapes the immune signals that affect brain function. People with depression and anxiety show measurably different microbiome compositions. Psychobiotics — probiotics specifically formulated to affect mental health — are showing early promise in clinical trials for anxiety and mild depression.

Active Trials

View all 192 trials
Feasibility and Acceptability of Peer Intervention for Improving Mental Health Among People Accessing Hormone CareRecruiting
Hormone CareMild DepressionAnxiety
The purpose of this study is to test whether the peer support program is acceptable, possible, and can improve mental he…
Ann Arbor, United StatesEst. completion Oct 2026
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Mobile Intervention for Mental Health of Family Caregivers in ThailandRecruiting
Depressive Symptoms, Generalized Anxiety, or Psychological Stress
The primary objective of this study is to evaluate the effectiveness of the CAMMA intervention in reducing psychological…
Bangkok, ThailandEst. completion Apr 30, 2028
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Cognitive Behavior Therapy in Psychiatric Inpatient CareRecruiting
Depression, Anxiety DisordersPsychiatric Inpatients
The current project aims to evaluate the extent to which psychological interventions based on Cognitive Behavioral Thera…
Stockholm, SwedenEst. completion Dec 31, 2027
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When good bacteria end up in the wrong place
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