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Home/Conditions/Mental Health & Gut-Brain Axis
Condition Guide

Mental Health & Gut-Brain Axis

The surprising conversation between your gut and your brain

Up to 95% of serotonin is made in the gut. The gut-brain axis is a two-way communication highway that influences mood, anxiety, and cognitive function. Microbiome research in mental health is one of the most exciting frontiers in medicine.

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The Microbiome Connection

How Mental Health & Gut-Brain Axis relates to gut health

Common Symptoms

  • Anxiety and depression
  • Brain fog and poor concentration
  • Sleep disturbances
  • IBS co-occurring with mood disorders
  • Chronic stress
  • Fatigue

How the Microbiome is Involved

Your gut microbiome produces neurotransmitters, regulates the vagus nerve, and shapes the immune signals that affect brain function. People with depression and anxiety show measurably different microbiome compositions. Psychobiotics — probiotics specifically formulated to affect mental health — are showing early promise in clinical trials for anxiety and mild depression.

Active Trials

View all 190 trials
The Mindful Smartphone Use StudyRecruiting
Depression and/or Anxiety SymptomsProblematic Phone Use Behavior
The goal of this clinical trial is to understand the feasibility and acceptability on a mindfulness-based intervention t…
Providence, United StatesEst. completion Feb 28, 2027
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Development & Validation of a Life Balance Program for Parents of Preschoolers: A Pilot StudyRecruiting
Parenting StressMental HealthOccupational Balance
This study aims to examine the relationships among life balance, parenting stress, and mental health in parents of presc…
Taichung, TaiwanEst. completion Jul 2027
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Improving Women's Mental Health Through Tele-based Wellbeing Centres in Bangladesh.Recruiting
DepressionAnxiety
1. Burden: Women in Bangladesh face a high mental health burden, with 22% experiencing mental disorders compared to …
Chāndpur, BangladeshEst. completion Jul 2027
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Related Conditions

Irritable Bowel Syndrome (IBS)
Calming the gut-brain storm
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Obesity & Metabolic Health
Your gut microbiome and your metabolism are deeply linked
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Small Intestinal Bacterial Overgrowth (SIBO)
When good bacteria end up in the wrong place
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