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Home/Conditions/Mental Health & Gut-Brain Axis
Condition Guide

Mental Health & Gut-Brain Axis

The surprising conversation between your gut and your brain

Up to 95% of serotonin is made in the gut. The gut-brain axis is a two-way communication highway that influences mood, anxiety, and cognitive function. Microbiome research in mental health is one of the most exciting frontiers in medicine.

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The Microbiome Connection

How Mental Health & Gut-Brain Axis relates to gut health

Common Symptoms

  • Anxiety and depression
  • Brain fog and poor concentration
  • Sleep disturbances
  • IBS co-occurring with mood disorders
  • Chronic stress
  • Fatigue

How the Microbiome is Involved

Your gut microbiome produces neurotransmitters, regulates the vagus nerve, and shapes the immune signals that affect brain function. People with depression and anxiety show measurably different microbiome compositions. Psychobiotics — probiotics specifically formulated to affect mental health — are showing early promise in clinical trials for anxiety and mild depression.

Active Trials

View all 189 trials
Pai.ACT - An Artificial Intelligence Driven Chatbot Assisted ACT (Full Scale RCT)Recruiting
Neurodevelopmental DisordersAutism Spectrum Disorder (ASD)Attention Deficit Disorder With Hyperactivity (ADHD)
Interventions for parents of children with NDD face two pivotal challenges. Firstly, many overlook the consequential inf…
Hong Kong, Hong KongEst. completion Dec 31, 2027
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Effects of Emotional Freedom Technique and Music Therapy in High-Risk PregnancyRecruiting
Preterm Premature Rupture of Membranes (PPROM)Premature Rupture of Membranes (PROM)High-Risk Pregnancy
Pregnancy is a physiological process; however, it is also a dynamic period during which obstetric and medical complicati…
Konya, Turkey (Türkiye)Est. completion Mar 2027
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MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal PatientsRecruiting
Anxiety DisordersStress Disorders, Post-TraumaticPregnancy, High RiskDepressive Disorder, MajorPregnancy ComplicationsADHD - Attention Deficit Disorder With Hyperactivity
Pregnant and postpartum patients hospitalized for medical complications experience high rates of depression, anxiety, an…
Indianapolis, United StatesEst. completion Sep 1, 2027
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