Your gut microbiome and your metabolism are deeply linked
Obesity is far more than a calorie equation. The trillions of microbes in the gut influence how energy is extracted from food, how fat is stored, and even how hungry you feel. Microbiome-targeted therapies may transform metabolic health.
View Recruiting TrialsHow Obesity & Metabolic Health relates to gut health
Studies comparing obese and lean twins show striking microbiome differences — even when genetics are identical. Gut bacteria regulate appetite hormones like GLP-1 and PYY, affect how much energy is extracted from food, and drive systemic inflammation linked to metabolic syndrome. Transferring microbiomes from lean donors to obese recipients has improved insulin sensitivity in early trials.
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