MicrobiomeTrials
  • Search Trials
  • Conditions
  • Learn
  • About
Data source: ClinicalTrials.gov
This site is for informational purposes only and does not provide medical advice, diagnosis, or treatment. Always consult your healthcare provider.
Sign up for updates
Home/Conditions/Cancer & the Microbiome
Condition Guide

Cancer & the Microbiome

The microbiome as ally in the fight against cancer

The gut microbiome influences cancer risk, treatment response, and side effect profiles. From colorectal cancer to immunotherapy outcomes, microbiome science is reshaping oncology — and clinical trials are uncovering how to harness it.

View Recruiting Trials

The Microbiome Connection

How Cancer & the Microbiome relates to gut health

Common Symptoms

  • Varies by cancer type
  • Immunotherapy side effects
  • Treatment-related gut disruption
  • Colorectal cancer risk factors

How the Microbiome is Involved

The microbiome affects cancer through multiple pathways: by modulating the immune system's tumor-fighting ability, by producing metabolites that can either protect or damage DNA, and by influencing whether immunotherapy drugs work. Patients with higher microbiome diversity tend to respond better to checkpoint inhibitors. FMT from responders to non-responders is being tested in trials.

Active Trials

View all 18889 trials
NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid TumorsRecruiting
Very Rare TumorsVery Rare CancersOther Solid TumorsSolid TumorPediatric Rare Tumors
Background: All childhood cancers are rare, but some are called very rare. Very rare cancers are diagnosed in 2 or fewe…
Bethesda, United StatesEst. completion Apr 1, 2035
View Trial →
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN StudyPhase 2Recruiting
Muscle Invasive Bladder Urothelial CarcinomaMuscle Invasive Renal Pelvis Urothelial CarcinomaMuscle Invasive Ureter Urothelial CarcinomaMuscle Invasive Urethral Urothelial CarcinomaStage II Bladder Urothelial Carcinoma AJCC v6 and v7Stage III Bladder Urothelial Carcinoma AJCC v6 and v7Stage IV Bladder Urothelial Carcinoma AJCC v7
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, kidney, ureter or uret…
Phoenix, United StatesEst. completion Sep 2, 2030
View Trial →
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)Phase 1Recruiting
B-cell Acute Lymphoblastic LeukemiaDiffuse Large B-cell LymphomaBurkitt LymphomaNeuroblastomaEwing Sarcoma
Substudy 01A is part of a platform study. The purpose of this study is to assess the efficacy and safety of zilovertamab…
Los Angeles, United StatesEst. completion Mar 31, 2029
View Trial →

Related Conditions

Inflammatory Bowel Disease (IBD)
Restoring balance to a disrupted gut
Explore
Obesity & Metabolic Health
Your gut microbiome and your metabolism are deeply linked
Explore
Mental Health & Gut-Brain Axis
The surprising conversation between your gut and your brain
Explore

Get notified about new Cancer & the Microbiome trials

We’ll email you when new recruiting trials for your condition are posted. No spam, ever.