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Home/Conditions/Cancer & the Microbiome
Condition Guide

Cancer & the Microbiome

The microbiome as ally in the fight against cancer

The gut microbiome influences cancer risk, treatment response, and side effect profiles. From colorectal cancer to immunotherapy outcomes, microbiome science is reshaping oncology — and clinical trials are uncovering how to harness it.

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The Microbiome Connection

How Cancer & the Microbiome relates to gut health

Common Symptoms

  • Varies by cancer type
  • Immunotherapy side effects
  • Treatment-related gut disruption
  • Colorectal cancer risk factors

How the Microbiome is Involved

The microbiome affects cancer through multiple pathways: by modulating the immune system's tumor-fighting ability, by producing metabolites that can either protect or damage DNA, and by influencing whether immunotherapy drugs work. Patients with higher microbiome diversity tend to respond better to checkpoint inhibitors. FMT from responders to non-responders is being tested in trials.

Active Trials

View all 18857 trials
A Study to Evaluate the Safety, Tolerability, and Efficacy of Pumitamig Alone or in Combination With Other Agents in Participants With Advanced Renal Cell Carcinoma (RCC) (ROSETTA RCC-208)Phase 1Recruiting
Advanced Renal Cell Carcinoma (RCC)
The purpose of this study is to evaluate the safety, tolerability, and efficacy of Pumitamig alone or in combination wit…
Palo Alto, United StatesEst. completion Nov 28, 2029
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Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS)Phase 2Recruiting
Colorectal Cancer Metastatic
This study will enroll patients with colorectal cancer that is locally advanced or metastatic. The tumor must be microsa…
Los Angeles, United StatesEst. completion Jun 30, 2027
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A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%Phase 3Recruiting
Non-small Cell Lung Cancer
The purpose of this study is to compare the efficacy of Nivolumab and Relatlimab in combination with chemotherapy to Pem…
Mobile, United StatesEst. completion Jul 30, 2030
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