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Home / Conditions / Cancer & the Microbiome Cancer & the Microbiome The microbiome as ally in the fight against cancer
The gut microbiome influences cancer risk, treatment response, and side effect profiles. From colorectal cancer to immunotherapy outcomes, microbiome science is reshaping oncology — and clinical trials are uncovering how to harness it.
View Recruiting Trials The Microbiome Connection How Cancer & the Microbiome relates to gut health
Common Symptoms How the Microbiome is Involved The microbiome affects cancer through multiple pathways: by modulating the immune system's tumor-fighting ability, by producing metabolites that can either protect or damage DNA, and by influencing whether immunotherapy drugs work. Patients with higher microbiome diversity tend to respond better to checkpoint inhibitors. FMT from responders to non-responders is being tested in trials.
Advanced Solid Tumor Metastatic Solid Tumor
The purpose of this study is to describe the safety, tolerability and early signs of efficacy of the antibody-cytokine f…
Hamburg, Germany Est. completion Dec 2026
Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Locally Recurrent Head and Neck Squamous Cell Carcinoma Locally Recurrent Hypopharyngeal Squamous Cell Carcinoma Locally Recurrent Laryngeal Squamous Cell Carcinoma Locally Recurrent Oral Cavity Squamous Cell Carcinoma Locally Recurrent Oropharyngeal Squamous Cell Carcinoma Stage II Laryngeal Cancer AJCC v8 Stage II Lip and Oral Cavity Cancer AJCC v8 Stage II Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage III Laryngeal Cancer AJCC v8 Stage III Lip and Oral Cavity Cancer AJCC v8 Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage IVA Laryngeal Cancer AJCC v8 Stage IVA Lip and Oral Cavity Cancer AJCC v8 Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage IVB Laryngeal Cancer AJCC v8 Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
This phase II trial tests the addition of chemotherapy, with carboplatin and paclitaxel, or chemo-immunotherapy, with ca…
Tucson, United States Est. completion Feb 1, 2033
Acute Myeloid Leukemia Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Acute Myeloid Leukemia Post Cytotoxic Therapy Acute Myeloid Leukemia, Myelodysplasia-Related Myelodysplastic Syndrome
This MyeloMATCH Master Screening and Reassessment Protocol (MSRP) evaluates the use of a screening tool and specific lab…
Birmingham, United States Est. completion May 15, 2029
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