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Home/Conditions/Cancer & the Microbiome
Condition Guide

Cancer & the Microbiome

The microbiome as ally in the fight against cancer

The gut microbiome influences cancer risk, treatment response, and side effect profiles. From colorectal cancer to immunotherapy outcomes, microbiome science is reshaping oncology — and clinical trials are uncovering how to harness it.

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The Microbiome Connection

How Cancer & the Microbiome relates to gut health

Common Symptoms

  • Varies by cancer type
  • Immunotherapy side effects
  • Treatment-related gut disruption
  • Colorectal cancer risk factors

How the Microbiome is Involved

The microbiome affects cancer through multiple pathways: by modulating the immune system's tumor-fighting ability, by producing metabolites that can either protect or damage DNA, and by influencing whether immunotherapy drugs work. Patients with higher microbiome diversity tend to respond better to checkpoint inhibitors. FMT from responders to non-responders is being tested in trials.

Active Trials

View all 18750 trials
Feasibility Study of a Transition Pathway at Discharge From Full Hospitalization in OncologyRecruiting
Cancer
Patient reported outcomes (PRO) measure the health status directly reported by the patients, without external interpreta…
Nîmes, FranceEst. completion Dec 2028
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Trial Investigating Visugromab and Nivolumab With or Without Docetaxel in 2L Treatment of Participants With Metastatic NSCLCPhase 2Recruiting
Metastatic Non-Squamous Non-Small Cell Lung CancerAdult Solid Tumor
This is an exploratory, signal-finding, randomized, placebo-controlled, blinded, multi-center phase 2b trial of the anti…
Birmingham, United StatesEst. completion Oct 1, 2029
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Combining High-frequency Micro-ultrasound and Multiparametric MRI Target Biopsy for Detecting Prostate CancerRecruiting
Prostatic Neoplasm of Uncertain Behavior
\*\*Study Goal:\*\* The purpose of this clinical trial is to determine if combining high-frequency micro-ultrasound with…
Salzburg, AustriaEst. completion Nov 1, 2027
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