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Home/Conditions/Inflammatory Bowel Disease (IBD)
Condition Guide

Inflammatory Bowel Disease (IBD)

Restoring balance to a disrupted gut

IBD is a group of chronic inflammatory conditions of the digestive tract. Emerging research shows the gut microbiome plays a central role — and new trials are exploring microbiome therapies that could change treatment forever.

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The Microbiome Connection

How Inflammatory Bowel Disease (IBD) relates to gut health

Common Symptoms

  • Persistent diarrhea
  • Abdominal pain and cramping
  • Rectal bleeding
  • Fatigue and weight loss
  • Reduced appetite

How the Microbiome is Involved

People with IBD consistently show lower microbial diversity and a reduction in beneficial bacteria like Faecalibacterium prausnitzii. This imbalance — called dysbiosis — triggers and sustains the chronic inflammation that defines the disease. Researchers believe restoring a healthy microbiome through FMT, probiotics, or diet-based interventions could reduce flares and even induce remission.

Active Trials

View all 564 trials
Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)Recruiting
Ulcerative Colitis
Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric ox…
Birmingham, United StatesEst. completion Sep 1, 2027
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A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)Phase 3Recruiting
Crohn's Disease
The purpose of this protocol is to evaluate the efficacy and safety of tulisokibart in participants with moderately to s…
Dothan, United StatesEst. completion Oct 30, 2028
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Risankizumab for Refractory Perianal Fistulizing Crohn's DiseasePhase 4Recruiting
Crohn DiseasePerianal FistulaPerianal Fistula Due to Crohn's DiseasePerianal Crohn's Disease
Crohn's disease is an inflammatory bowel disease characterized by relapses and remissions, causing lesions throughout th…
Nishinomiya, JapanEst. completion Oct 13, 2028
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Related Conditions

Crohn's Disease
Tackling one of the gut's toughest conditions
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From chronic flares to lasting remission
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Irritable Bowel Syndrome (IBS)
Calming the gut-brain storm
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