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Home/Conditions/Inflammatory Bowel Disease (IBD)
Condition Guide

Inflammatory Bowel Disease (IBD)

Restoring balance to a disrupted gut

IBD is a group of chronic inflammatory conditions of the digestive tract. Emerging research shows the gut microbiome plays a central role — and new trials are exploring microbiome therapies that could change treatment forever.

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The Microbiome Connection

How Inflammatory Bowel Disease (IBD) relates to gut health

Common Symptoms

  • Persistent diarrhea
  • Abdominal pain and cramping
  • Rectal bleeding
  • Fatigue and weight loss
  • Reduced appetite

How the Microbiome is Involved

People with IBD consistently show lower microbial diversity and a reduction in beneficial bacteria like Faecalibacterium prausnitzii. This imbalance — called dysbiosis — triggers and sustains the chronic inflammation that defines the disease. Researchers believe restoring a healthy microbiome through FMT, probiotics, or diet-based interventions could reduce flares and even induce remission.

Active Trials

View all 571 trials
A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative ColitisRecruiting
Ulcerative ColitisCrohn Disease
Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiot…
Roma, ItalyEst. completion Sep 14, 2026
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Autologous Stem Cell Transplant for Crohn's DiseasePhase 2Recruiting
Crohn Disease
Crohn's Disease (CD) is an inflammatory bowel disease. It can lead to significant complications and discomfort in the st…
New York, United StatesEst. completion Oct 2028
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Study of XmAb942 in Healthy Participants and Participants With Ulcerative ColitisPhase 1Recruiting
Ulcerative Colitis (UC)
The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb…
Scottsdale, United StatesEst. completion Apr 2028
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Related Conditions

Crohn's Disease
Tackling one of the gut's toughest conditions
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Ulcerative Colitis
From chronic flares to lasting remission
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Irritable Bowel Syndrome (IBS)
Calming the gut-brain storm
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