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Home/Conditions/Inflammatory Bowel Disease (IBD)
Condition Guide

Inflammatory Bowel Disease (IBD)

Restoring balance to a disrupted gut

IBD is a group of chronic inflammatory conditions of the digestive tract. Emerging research shows the gut microbiome plays a central role — and new trials are exploring microbiome therapies that could change treatment forever.

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The Microbiome Connection

How Inflammatory Bowel Disease (IBD) relates to gut health

Common Symptoms

  • Persistent diarrhea
  • Abdominal pain and cramping
  • Rectal bleeding
  • Fatigue and weight loss
  • Reduced appetite

How the Microbiome is Involved

People with IBD consistently show lower microbial diversity and a reduction in beneficial bacteria like Faecalibacterium prausnitzii. This imbalance — called dysbiosis — triggers and sustains the chronic inflammation that defines the disease. Researchers believe restoring a healthy microbiome through FMT, probiotics, or diet-based interventions could reduce flares and even induce remission.

Active Trials

View all 556 trials
A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier HomeostasisRecruiting
Inflammatory Bowel Disease
Crohn's Disease (CD) and Ulcerative Colitis (UC), collectively known as inflammatory bowel disease (IBD), are two of the…
Chicago, United StatesEst. completion Sep 1, 2026
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TNFi Plus Low-Dose Upadacitinib vs TNFi Intensification in Crohn's Disease With Suboptimal ResponsePhase 4Recruiting
Crohn Disease (CD)
This multicenter, randomized, controlled trial aims to evaluate the efficacy and safety of standard-dose tumor necrosis …
Guangzhou, ChinaEst. completion Dec 31, 2028
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AIM-IBD: A Microbiome-Targeted Supplement in Mild-to-Moderate Ulcerative ColitisRecruiting
Ulcerative Colitis (UC)Inflammatory Bowel Disease (IBD)Colitis
This Phase 2b randomized, double-blind, placebo-controlled, multicenter trial will evaluate the efficacy and safety of a…
Izmir, Turkey (Türkiye)Est. completion May 30, 2027
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Related Conditions

Crohn's Disease
Tackling one of the gut's toughest conditions
Explore
Ulcerative Colitis
From chronic flares to lasting remission
Explore
Irritable Bowel Syndrome (IBS)
Calming the gut-brain storm
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