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Home/Conditions/Inflammatory Bowel Disease (IBD)
Condition Guide

Inflammatory Bowel Disease (IBD)

Restoring balance to a disrupted gut

IBD is a group of chronic inflammatory conditions of the digestive tract. Emerging research shows the gut microbiome plays a central role — and new trials are exploring microbiome therapies that could change treatment forever.

View Recruiting Trials

The Microbiome Connection

How Inflammatory Bowel Disease (IBD) relates to gut health

Common Symptoms

  • Persistent diarrhea
  • Abdominal pain and cramping
  • Rectal bleeding
  • Fatigue and weight loss
  • Reduced appetite

How the Microbiome is Involved

People with IBD consistently show lower microbial diversity and a reduction in beneficial bacteria like Faecalibacterium prausnitzii. This imbalance — called dysbiosis — triggers and sustains the chronic inflammation that defines the disease. Researchers believe restoring a healthy microbiome through FMT, probiotics, or diet-based interventions could reduce flares and even induce remission.

Active Trials

View all 571 trials
IBD Strong Peer2Peer for Self-Management of Psychological DistressRecruiting
Inflammatory Bowel DiseasesUlcerative ColitisCrohn Disease
Psychological distress (PD) as a result of inflammatory bowel disease (IBD) is prevalent and associated with worse disea…
Halifax, CanadaEst. completion Mar 2027
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Confirmatory Clinical Study in Active Ulcerative ColitisPhase 2Recruiting
Colitis, Ulcerative
The main goal of the study is to check if MH002 works and is safe to use. In a previous study in 45 patients with Ulcera…
Miami, United StatesEst. completion Sep 2027
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A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414 Administered Orally in Healthy Adult Participants and Patients With Active Ulcerative ColitisPhase 1Recruiting
Ulcerative Colitis (UC)
A study to investigate the safety, tolerability, and pharmacokinetics (PK) of ONO-6414 orally in healthy adult participa…
Miami, United StatesEst. completion Dec 31, 2027
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