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Home/Conditions/Inflammatory Bowel Disease (IBD)
Condition Guide

Inflammatory Bowel Disease (IBD)

Restoring balance to a disrupted gut

IBD is a group of chronic inflammatory conditions of the digestive tract. Emerging research shows the gut microbiome plays a central role — and new trials are exploring microbiome therapies that could change treatment forever.

View Recruiting Trials

The Microbiome Connection

How Inflammatory Bowel Disease (IBD) relates to gut health

Common Symptoms

  • Persistent diarrhea
  • Abdominal pain and cramping
  • Rectal bleeding
  • Fatigue and weight loss
  • Reduced appetite

How the Microbiome is Involved

People with IBD consistently show lower microbial diversity and a reduction in beneficial bacteria like Faecalibacterium prausnitzii. This imbalance — called dysbiosis — triggers and sustains the chronic inflammation that defines the disease. Researchers believe restoring a healthy microbiome through FMT, probiotics, or diet-based interventions could reduce flares and even induce remission.

Active Trials

View all 564 trials
Multi-omics Dissection of Gut Microbiome Engraftment During FMTRecruiting
Recurrent C. Difficile (rCDI)Ulcerative Colitis (UC)Metabolic Syndrome (MetS)
The gut microbiota plays a key role in immunity and metabolism and contributes to diseases such as recurrent C. difficil…
Rome, ItalyEst. completion Jan 19, 2029
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Open-label Single-arm Study to Assess the Efficacy of Mirikizumab in Patients With Inflammatory Strictures Due to CDPhase 4Recruiting
Crohn Disease
This is an open-label, single-arm, phase 4 study to assess the safety and efficacy of mirikizumab in approximately 60 pa…
Miami, United StatesEst. completion Sep 1, 2027
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Immune Regulation in Ulcerative Colitis or Crohn s DiseaseRecruiting
Inflammatory Bowel DiseaseUlcerative ColitisChrohn's Disease
This study will investigate in patients with Crohn s disease and ulcerative colitis how the body s immune system control…
Bethesda, United States
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Related Conditions

Crohn's Disease
Tackling one of the gut's toughest conditions
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Ulcerative Colitis
From chronic flares to lasting remission
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Irritable Bowel Syndrome (IBS)
Calming the gut-brain storm
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