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Home/Conditions/Ulcerative Colitis
Condition Guide

Ulcerative Colitis

From chronic flares to lasting remission

Ulcerative colitis (UC) causes inflammation and ulcers in the colon lining, leading to painful flares. Of all IBD conditions, UC has seen some of the most exciting microbiome trial results — with FMT achieving remission in multiple studies.

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The Microbiome Connection

How Ulcerative Colitis relates to gut health

Common Symptoms

  • Bloody diarrhea
  • Urgent need to defecate
  • Abdominal cramping
  • Weight loss
  • Fatigue
  • Inability to defecate despite urgency

How the Microbiome is Involved

UC is closely linked to an overgrowth of harmful bacteria and a loss of commensal species that regulate immune tolerance in the colon. Short-chain fatty acids like butyrate — produced by healthy gut bacteria — are depleted in UC, leaving the colon lining vulnerable and inflamed. Microbiome therapies aim to directly address this deficit.

Active Trials

View all 278 trials
IBD Strong Peer2Peer for Self-Management of Psychological DistressRecruiting
Inflammatory Bowel DiseasesUlcerative ColitisCrohn Disease
Psychological distress (PD) as a result of inflammatory bowel disease (IBD) is prevalent and associated with worse disea…
Halifax, CanadaEst. completion Mar 2027
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Confirmatory Clinical Study in Active Ulcerative ColitisPhase 2Recruiting
Colitis, Ulcerative
The main goal of the study is to check if MH002 works and is safe to use. In a previous study in 45 patients with Ulcera…
Miami, United StatesEst. completion Sep 2027
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A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414 Administered Orally in Healthy Adult Participants and Patients With Active Ulcerative ColitisPhase 1Recruiting
Ulcerative Colitis (UC)
A study to investigate the safety, tolerability, and pharmacokinetics (PK) of ONO-6414 orally in healthy adult participa…
Miami, United StatesEst. completion Dec 31, 2027
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Related Conditions

Inflammatory Bowel Disease (IBD)
Restoring balance to a disrupted gut
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Crohn's Disease
Tackling one of the gut's toughest conditions
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C. difficile (C. diff)
The condition where microbiome therapy works best
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