Condition Guide

Ulcerative Colitis

From chronic flares to lasting remission

Ulcerative colitis (UC) causes inflammation and ulcers in the colon lining, leading to painful flares. Of all IBD conditions, UC has seen some of the most exciting microbiome trial results — with FMT achieving remission in multiple studies.

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The Microbiome Connection

How Ulcerative Colitis relates to gut health

Common Symptoms

Bloody diarrhea
Urgent need to defecate
Abdominal cramping
Weight loss
Fatigue
Inability to defecate despite urgency

How the Microbiome is Involved

UC is closely linked to an overgrowth of harmful bacteria and a loss of commensal species that regulate immune tolerance in the colon. Short-chain fatty acids like butyrate — produced by healthy gut bacteria — are depleted in UC, leaving the colon lining vulnerable and inflamed. Microbiome therapies aim to directly address this deficit.

Active Trials

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Related Conditions

Inflammatory Bowel Disease (IBD)

Restoring balance to a disrupted gut

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Crohn's Disease

Tackling one of the gut's toughest conditions

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C. difficile (C. diff)

The condition where microbiome therapy works best

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