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Home/Conditions/Ulcerative Colitis
Condition Guide

Ulcerative Colitis

From chronic flares to lasting remission

Ulcerative colitis (UC) causes inflammation and ulcers in the colon lining, leading to painful flares. Of all IBD conditions, UC has seen some of the most exciting microbiome trial results — with FMT achieving remission in multiple studies.

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The Microbiome Connection

How Ulcerative Colitis relates to gut health

Common Symptoms

  • Bloody diarrhea
  • Urgent need to defecate
  • Abdominal cramping
  • Weight loss
  • Fatigue
  • Inability to defecate despite urgency

How the Microbiome is Involved

UC is closely linked to an overgrowth of harmful bacteria and a loss of commensal species that regulate immune tolerance in the colon. Short-chain fatty acids like butyrate — produced by healthy gut bacteria — are depleted in UC, leaving the colon lining vulnerable and inflamed. Microbiome therapies aim to directly address this deficit.

Active Trials

View all 277 trials
A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative ColitisRecruiting
Ulcerative ColitisCrohn Disease
Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiot…
Roma, ItalyEst. completion Sep 14, 2026
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Study of XmAb942 in Healthy Participants and Participants With Ulcerative ColitisPhase 1Recruiting
Ulcerative Colitis (UC)
The Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of XmAb…
Scottsdale, United StatesEst. completion Apr 2028
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An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative ColitisPhase 1Recruiting
Active Ulcerative Colitis
The purpose of this study is to evaluate the disease-drug-drug interaction (DDDI) potential of afimkibart (also known as…
Chula Vista, United StatesEst. completion Jul 31, 2027
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Related Conditions

Inflammatory Bowel Disease (IBD)
Restoring balance to a disrupted gut
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Tackling one of the gut's toughest conditions
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C. difficile (C. diff)
The condition where microbiome therapy works best
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