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Home/Conditions/Crohn's Disease
Condition Guide

Crohn's Disease

Tackling one of the gut's toughest conditions

Crohn's disease causes inflammation anywhere along the digestive tract and can be a serious, lifelong condition. Microbiome research is illuminating why some people develop Crohn's — and opening doors to new therapies.

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The Microbiome Connection

How Crohn's Disease relates to gut health

Common Symptoms

  • Severe diarrhea
  • Abdominal pain and tenderness
  • Fatigue
  • Fever and night sweats
  • Unintended weight loss
  • Blood in stool

How the Microbiome is Involved

Crohn's patients show a striking loss of microbial diversity, particularly of bacteria that produce short-chain fatty acids (SCFAs) which protect the gut lining. A 'leaky gut' caused by this imbalance allows microbes to trigger inflammatory immune responses. Researchers are studying whether repopulating the microbiome with specific strains can suppress this immune overreaction and heal the intestinal barrier.

Active Trials

View all 307 trials
A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier HomeostasisRecruiting
Inflammatory Bowel Disease
Crohn's Disease (CD) and Ulcerative Colitis (UC), collectively known as inflammatory bowel disease (IBD), are two of the…
Chicago, United StatesEst. completion Sep 1, 2026
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TNFi Plus Low-Dose Upadacitinib vs TNFi Intensification in Crohn's Disease With Suboptimal ResponsePhase 4Recruiting
Crohn Disease (CD)
This multicenter, randomized, controlled trial aims to evaluate the efficacy and safety of standard-dose tumor necrosis …
Guangzhou, ChinaEst. completion Dec 31, 2028
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A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)Phase 3Recruiting
Crohn's Disease
The purpose of this protocol is to evaluate the efficacy and safety of tulisokibart in participants with moderately to s…
Dothan, United StatesEst. completion Oct 30, 2028
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