MicrobiomeTrials
  • Search Trials
  • Conditions
  • Learn
  • About
Data source: ClinicalTrials.gov
This site is for informational purposes only and does not provide medical advice, diagnosis, or treatment. Always consult your healthcare provider.
Sign up for updates
Home/Conditions/Crohn's Disease
Condition Guide

Crohn's Disease

Tackling one of the gut's toughest conditions

Crohn's disease causes inflammation anywhere along the digestive tract and can be a serious, lifelong condition. Microbiome research is illuminating why some people develop Crohn's — and opening doors to new therapies.

View Recruiting Trials

The Microbiome Connection

How Crohn's Disease relates to gut health

Common Symptoms

  • Severe diarrhea
  • Abdominal pain and tenderness
  • Fatigue
  • Fever and night sweats
  • Unintended weight loss
  • Blood in stool

How the Microbiome is Involved

Crohn's patients show a striking loss of microbial diversity, particularly of bacteria that produce short-chain fatty acids (SCFAs) which protect the gut lining. A 'leaky gut' caused by this imbalance allows microbes to trigger inflammatory immune responses. Researchers are studying whether repopulating the microbiome with specific strains can suppress this immune overreaction and heal the intestinal barrier.

Active Trials

View all 321 trials
A Clinical Trial of Taibowei® Adalimumab Injection in the Treatment of Chinese Pediatric Patients With Moderately to Severely Active Crohn's DiseasePhase 4Recruiting
Children Aged 6 Years and Above With Moderate - to - Severe Active Crohn's Disease
This study is a real - world clinical research of adalimumab. The project plans to enroll 30 subjects, aiming to evaluat…
Guangzhou, ChinaEst. completion Mar 2029
View Trial →
IBD Strong Peer2Peer for Self-Management of Psychological DistressRecruiting
Inflammatory Bowel DiseasesUlcerative ColitisCrohn Disease
Psychological distress (PD) as a result of inflammatory bowel disease (IBD) is prevalent and associated with worse disea…
Halifax, CanadaEst. completion Mar 2027
View Trial →
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)Phase 3Recruiting
Crohn DiseaseColitis, Ulcerative
Researchers want to learn more about tulisokibart (also known as MK-7240) in an extension study. Tulisokibart is a medic…
Bristol, United StatesEst. completion Dec 17, 2037
View Trial →

Related Conditions

Inflammatory Bowel Disease (IBD)
Restoring balance to a disrupted gut
Explore
Ulcerative Colitis
From chronic flares to lasting remission
Explore
Irritable Bowel Syndrome (IBS)
Calming the gut-brain storm
Explore

Get notified about new Crohn's Disease trials

We’ll email you when new recruiting trials for your condition are posted. No spam, ever.