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Home/Conditions/Irritable Bowel Syndrome (IBS)
Condition Guide

Irritable Bowel Syndrome (IBS)

Calming the gut-brain storm

IBS affects millions worldwide with symptoms that can be debilitating, yet the underlying cause has long been mysterious. New research points to the gut microbiome and the gut-brain axis as key drivers — and trials are finding promising paths to relief.

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The Microbiome Connection

How Irritable Bowel Syndrome (IBS) relates to gut health

Common Symptoms

  • Bloating and gas
  • Abdominal cramping
  • Diarrhea, constipation, or alternating both
  • Urgency or incomplete bowel movements
  • Nausea

How the Microbiome is Involved

People with IBS often have a distinct microbiome signature — with reduced Bifidobacterium and Lactobacillus species and altered gut motility signals. The gut-brain axis plays a huge role: gut bacteria produce neurotransmitters like serotonin that directly affect bowel behavior and mood. Restoring microbial balance may calm both the gut and nervous system.

Active Trials

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Browse all trials for Irritable Bowel Syndrome (IBS) →

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The surprising conversation between your gut and your brain
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