SIBO occurs when bacteria that normally live in the colon migrate into the small intestine, causing fermentation, malabsorption, and pain. The microbiome connection here is front and center — and new trials are exploring targeted treatments.
How Small Intestinal Bacterial Overgrowth (SIBO) relates to gut health
Common Symptoms
Bloating and distension
Gas and belching
Diarrhea or constipation
Abdominal pain
Nutritional deficiencies
Brain fog and fatigue
How the Microbiome is Involved
In SIBO, the microbial ecosystem of the small intestine becomes colonized by organisms that belong in the large intestine. These bacteria ferment carbohydrates prematurely, producing excess hydrogen or methane gas and damaging the gut lining. Treatment focuses on reducing bacterial overgrowth while also restoring proper gut motility and microbiome balance.