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Home/Conditions/C. difficile (C. diff)
Condition Guide

C. difficile (C. diff)

The condition where microbiome therapy works best

C. difficile is a dangerous bacterial infection that thrives when the gut microbiome is disrupted — often after antibiotic use. FMT has become a landmark treatment, with cure rates over 90% in clinical trials.

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The Microbiome Connection

How C. difficile (C. diff) relates to gut health

Common Symptoms

  • Watery diarrhea (3 or more times per day)
  • Fever
  • Nausea
  • Abdominal pain or tenderness
  • Loss of appetite

How the Microbiome is Involved

C. diff infection is almost entirely caused by microbiome disruption. Antibiotics wipe out protective gut bacteria, leaving a vacuum that C. difficile colonizes and exploits. Restoring a healthy, diverse microbiome — through FMT or next-generation microbiome therapies like SER-109 — directly displaces C. diff and prevents relapse.

Active Trials

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